Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Silverchair Information Systems full text link Silverchair Information Systems Free PMC article
Full text links

Actions

.2017 Aug 1;9(8):2013-2022.
doi: 10.1093/gbe/evx118.

Discerning the Origins of the Negritos, First Sundaland People: Deep Divergence and Archaic Admixture

Affiliations

Discerning the Origins of the Negritos, First Sundaland People: Deep Divergence and Archaic Admixture

Timothy A Jinam et al. Genome Biol Evol..

Abstract

Human presence in Southeast Asia dates back to at least 40,000 years ago, when the current islands formed a continental shelf called Sundaland. In the Philippine Islands, Peninsular Malaysia, and Andaman Islands, there exist indigenous groups collectively called Negritos whose ancestry can be traced to the "First Sundaland People." To understand the relationship between these Negrito groups and their demographic histories, we generated genome-wide single nucleotide polymorphism data in the Philippine Negritos and compared them with existing data from other populations. Phylogenetic tree analyses show that Negritos are basal to other East and Southeast Asians, and that they diverged from West Eurasians at least 38,000 years ago. We also found relatively high traces of Denisovan admixture in the Philippine Negritos, but not in the Malaysian and Andamanese groups, suggesting independent introgression and/or parallel losses involving Denisovan introgressed regions. Shared genetic loci between all three Negrito groups could be related to skin pigmentation, height, facial morphology and malarial resistance. These results show the unique status of Negrito groups as descended from the First Sundaland People.

Keywords: Denisovan; Negritos; Southeast Asia; admixture; population genetics.

© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

PubMed Disclaimer

Figures

<sc>Fig</sc>. 1.
Fig. 1.
—Principal component analysis plot of (A) Andamanese (Jarawa and Onge), Malaysian Negritos (Batek, Jehai, and Kintak), and Philippine Negritos (Aeta, Agta, Mamanwa, and Batak) with non-Negrito Southeast Asians; (B) Malaysian and Philippine populations. Mly-NN, Malaysian non-Negritos (Temuan and Bidayuh); Phil-NN, Philippine non-Negritos (Tagalog and Visayan; Manobo was treated separately).
<sc>Fig</sc>. 2.
Fig. 2.
—Results of ADMIXTURE assumingk = 2 tok = 7. Each vertical line represents an individual and the different colors represent various ancestry components. Negrito group labels are indicated in red text.
<sc>Fig</sc>. 3.
Fig. 3.
—(A) Neighbor-joining tree constructed from Nei’s standard genetic distance. (B) Maximum-likelihood tree generated using Treemix, assuming five geneflow events, with only three shown for clarity. Numbers in red and blue text represent average migration weights and bootstrap supports for branches out of 1,000 bootstrap replicates, respectively. Only bootstrap values >50% are shown.
<sc>Fig</sc>. 4.
Fig. 4.
—Estimation of Denisovan ancestry in Southeast Asians using the f4 ratio test. Proportion of Denisovan ancestry is represented by colored circles. Phil-NN, Philippine non-Negritos (Tagalog, Visayan, and Manobo).
<sc>Fig</sc>. 5.
Fig. 5.
—(A) Distribution of Denisovan allele-sharing in Papuan, Australian Aborigine, and Aeta (Philippine Negrito) published genome sequences, calculated in 1,000 SNP blocks and (B) Example of Denisovan allele-sharing patterns in chromosome 3 for Papuan and Aeta.
See this image and copyright information in PMC

References

    1. Adhikari K, et al. 2016. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat Commun. 7:10815.. - PMC - PubMed
    1. Aghakhanian F, et al. 2015. Unravelling the genetic history of negritos and indigenous populations of southeast Asia. Genome Biol Evol. 7:1206–1215. - PMC - PubMed
    1. Alexander DH, Novembre J, Lange K.. 2009. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19:1655–1664. - PMC - PubMed
    1. Barker G, et al. 2007. The ‘human revolution’ in lowland tropical Southeast Asia: the antiquity and behavior of anatomically modern humans at Niah Cave (Sarawak, Borneo). J Hum Evol. 52:243–261. - PubMed
    1. Barrows DP. 1910. The Negrito and allied types in the Philippines. Am Anthropol. 12:358–376.

MeSH terms

LinkOut - more resources

Full text links
Silverchair Information Systems full text link Silverchair Information Systems Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2026 Movatter.jp