Toxicology of Lead and Its Damage to Mammalian Organs
- PMID:28731309
- DOI: 10.1515/9783110434330-016
Toxicology of Lead and Its Damage to Mammalian Organs
Abstract
The toxicity of lead has been appreciated for centuries. Lead is a commonly used metal in industrialized nations, which results in the release of lead into the environment. Governmental agencies regulate the amount of lead permissible for workers to be exposed to; however, unregulated environmental lead exposure is a high concern. While essential metals have physiologic roles, there are no health benefits from lead intake. In this chapter, we discuss sources of lead exposure, the absorption, distribution, and elimination of lead from the human body, and molecular mechanisms of lead-induced toxicity. We also discuss the evidence on the association between lead exposure and blood pressure, and the influence of sociodemographic, lifestyle and environmental determinants of lead exposure in the general population. We highlight the effects on the nervous system, kidney, immune system, blood, reproductive system, and bones.
Similar articles
- Neurotoxicity of metals.Caito S, Aschner M.Caito S, et al.Handb Clin Neurol. 2015;131:169-89. doi: 10.1016/B978-0-444-62627-1.00011-1.Handb Clin Neurol. 2015.PMID:26563789Review.
- Lead contamination in Uruguay: the "La Teja" neighborhood case.Mañay N, Cousillas AZ, Alvarez C, Heller T.Mañay N, et al.Rev Environ Contam Toxicol. 2008;195:93-115.Rev Environ Contam Toxicol. 2008.PMID:18418955Review.
- Lead Exposure in Different Organs of Mammals and Prevention by Curcumin-Nanocurcumin: a Review.Pal M, Sachdeva M, Gupta N, Mishra P, Yadav M, Tiwari A.Pal M, et al.Biol Trace Elem Res. 2015 Dec;168(2):380-91. doi: 10.1007/s12011-015-0366-8. Epub 2015 May 26.Biol Trace Elem Res. 2015.PMID:26005056Review.
- Toxicity, mutagenicity and teratogenicity of lead.Gerber GB, Léonard A, Jacquet P.Gerber GB, et al.Mutat Res. 1980 Sep;76(2):115-41. doi: 10.1016/0165-1110(80)90006-8.Mutat Res. 1980.PMID:7005666Review.No abstract available.
- Lead hepatotoxicity & potential health effects.Mudipalli A.Mudipalli A.Indian J Med Res. 2007 Dec;126(6):518-27.Indian J Med Res. 2007.PMID:18219078Review.
Cited by
- Lead concentrations in antlers of European roe deer (Capreolus capreolus) from an agricultural area in Northern Germany over a 119-year period-a historical biomonitoring study.Ludolphy C, Kierdorf U, Kierdorf H.Ludolphy C, et al.Environ Sci Pollut Res Int. 2021 Oct;28(40):56069-56078. doi: 10.1007/s11356-021-14538-6. Epub 2021 May 27.Environ Sci Pollut Res Int. 2021.PMID:34047901Free PMC article.
- Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats.BaSalamah MA, Abdelghany AH, El-Boshy M, Ahmad J, Idris S, Refaat B.BaSalamah MA, et al.Sci Rep. 2018 Mar 19;8(1):4853. doi: 10.1038/s41598-018-23258-w.Sci Rep. 2018.PMID:29556070Free PMC article.
- Root Metabolite Differences in Two Maize Varieties Under Lead (Pb) Stress.Zhang H, Qin Y, Huang K, Zhan F, Li R, Chen J.Zhang H, et al.Front Plant Sci. 2021 Nov 23;12:656074. doi: 10.3389/fpls.2021.656074. eCollection 2021.Front Plant Sci. 2021.PMID:34887879Free PMC article.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical