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Herpes Zoster

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Herpes Zoster

Pragya A. Nair et al.
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Excerpt

Herpes zoster is commonly known as shingles. It is a viral disease caused by reactivation of varicella-zoster virus which remains dormant in the sensory ganglia of the cranial nerve or the dorsal root ganglia after a previous varicella infection. Varicella is commonly known as chickenpox; it occurs in children while herpes zoster occurs in adults or the elderly.

It is believed that zoster occurs due to the failure of the immune defense system to control the latent replication of the virus. The incidence of herpes zoster is strongly correlated to the immune status. Individuals who maintain a high level of immunity rarely develop shingles. The infection is not benign and can present in many ways. Even after herpes zoster resolves, many patients continue to suffer from moderate to severe pain known as postherpetic neuralgia.

Copyright © 2025, StatPearls Publishing LLC.

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Conflict of interest statement

Disclosure:Pragya Nair declares no relevant financial relationships with ineligible companies.

Disclosure:Bhupendra Patel declares no relevant financial relationships with ineligible companies.

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References

    1. Heineman TC, Cunningham A, Levin M. Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine. Curr Opin Immunol. 2019 Aug;59:42-48. - PubMed
    1. Watanabe D. [Cutaneous Herpesvirus Infection]. Brain Nerve. 2019 Apr;71(4):302-308. - PubMed
    1. Yu YH, Lin Y, Sun PJ. Segmental zoster abdominal paresis mimicking an abdominal hernia: A case report and literature review. Medicine (Baltimore) 2019 Apr;98(15):e15037. - PMC - PubMed
    1. Senderovich H, Grewal J, Mujtaba M. Herpes zoster vaccination efficacy in the long-term care facility population: a qualitative systematic review. Curr Med Res Opin. 2019 Aug;35(8):1451-1462. - PubMed
    1. Warren-Gash C, Forbes HJ, Williamson E, Breuer J, Hayward AC, Mavrodaris A, Ridha BH, Rossor MN, Thomas SL, Smeeth L. Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis. Sci Rep. 2019 Mar 18;9(1):4743. - PMC - PubMed

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