The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance
- PMID:2866784
- PMCID: PMC1400899
- DOI: 10.1111/j.1365-2125.1985.tb05078.x
The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance
Abstract
The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion, choice reaction time and on subjective feelings were studied in a double blind cross-over study in eight volunteers. Testing was performed on nights 1 and 6 of treatment. Nitrazepam, a benzodiazepine with a long elimination half-life produced a residual performance impairment on night 1 that had disappeared by night 6, despite higher serum concentrations of the drug on the sixth night of treatment. Temazepam, with a shorter elimination half-life produced no significant performance impairment on night 1, but by night 6 a significant impairment of saccadic eye movements (P less than 0.05), was seen 1 h after drug intake. We conclude that tolerance developed to the sedative action of nitrazepam over the 6 night period of the study. No evidence of tolerance was seen with temazepam.
Similar articles
- The effects of repeated doses of temazepam and nitrazepam on several measures of human performance.Griffiths AN, Tedeschi G, Richens A.Griffiths AN, et al.Acta Psychiatr Scand Suppl. 1986;332:119-26. doi: 10.1111/j.1600-0447.1986.tb08988.x.Acta Psychiatr Scand Suppl. 1986.PMID:2883819Clinical Trial.
- An investigation into the interaction between ethanol at low doses and the benzodiazepines nitrazepam and temazepam on psychomotor performance in normal subjects.Taberner PV, Roberts CJ, Shrosbree E, Pycock CJ, English L.Taberner PV, et al.Psychopharmacology (Berl). 1983;81(4):321-6. doi: 10.1007/BF00427570.Psychopharmacology (Berl). 1983.PMID:6140699Clinical Trial.
- Acute effects of temazepam and nitrazepam on psychomotor skills and memory.Liljequist R, Mattila MJ.Liljequist R, et al.Acta Pharmacol Toxicol (Copenh). 1979 May;44(5):364-9. doi: 10.1111/j.1600-0773.1979.tb02346.x.Acta Pharmacol Toxicol (Copenh). 1979.PMID:38627Clinical Trial.
- Temazepam: a review of its pharmacological properties and therapeutic efficacy as an hypnotic.Heel RC, Brogden RN, Speight TM, Avery GS.Heel RC, et al.Drugs. 1981 May;21(5):321-40. doi: 10.2165/00003495-198121050-00001.Drugs. 1981.PMID:6112127Review.
- Temazepam (Restoril, Sandoz Pharmaceuticals).McElnay JC, Jones ME, Alexander B.McElnay JC, et al.Drug Intell Clin Pharm. 1982 Sep;16(9):650-6. doi: 10.1177/106002808201600902.Drug Intell Clin Pharm. 1982.PMID:6127197Review.
Cited by
- Saccadic eye movements analysis as a measure of drug effect on central nervous system function.Tedeschi G, Quattrone A, Bonavita V.Tedeschi G, et al.Ital J Neurol Sci. 1986 Apr;7(2):223-31. doi: 10.1007/BF02230885.Ital J Neurol Sci. 1986.PMID:2873111
- Effects of oxazepam on eye movements and performance in vigilance tasks with static and dynamic stimuli.van Leeuwen TH, Verbaten MN, Koelega HS, Camfferman G, van der Gugten J, Slangen JL.van Leeuwen TH, et al.Psychopharmacology (Berl). 1994 Feb;114(1):109-18. doi: 10.1007/BF02245451.Psychopharmacology (Berl). 1994.PMID:7846192Clinical Trial.
- Pharmacological treatment effects on eye movement control.Reilly JL, Lencer R, Bishop JR, Keedy S, Sweeney JA.Reilly JL, et al.Brain Cogn. 2008 Dec;68(3):415-35. doi: 10.1016/j.bandc.2008.08.026.Brain Cogn. 2008.PMID:19028266Free PMC article.Review.
References
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources