Review
doi: 10.1016/j.msec.2017.04.068. Epub 2017 Apr 18.Non-viral strategies for ocular gene delivery
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- PMID:28532005
- DOI: 10.1016/j.msec.2017.04.068
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Review
Non-viral strategies for ocular gene delivery
Ana V Oliveira et al. Mater Sci Eng C Mater Biol Appl..
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Abstract
The success of gene therapy relies on efficient gene transfer and stable transgene expression. The in vivo efficiency is determined by the delivery vector, route of administration, therapeutic gene, and target cells. While some requirements are common to several strategies, others depend on the target disease and transgene product. Consequently, it is unlikely that a single system is suitable for all applications. This review examines current gene therapy strategies, focusing on non-viral approaches and the use of natural polymers with the eye, and particularly the retina, as their gene delivery target.
Keywords: Eye; Gene therapy; Non-viral vectors; Retina.
Copyright © 2017 Elsevier B.V. All rights reserved.
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