Review
doi: 10.2741/4539.The immunological function of GABAergic system
Affiliations
- PMID:28199198
- DOI: 10.2741/4539
Item in Clipboard
Review
The immunological function of GABAergic system
Chenlu Wu et al. Front Biosci (Landmark Ed)..
Free article Display options
Format
Display options
Format
Abstract
As a well-known inhibitory neurotransmitter in the central nervous system, gamma-aminobutyric acid also has critical roles in immune system. Immune cells (e.g., lymphocytes, macrophages) express the components of GABAergic system, including GABA receptors, GABA transporters, and GABA metabolic enzymes. The functions of immune cells are highly impacted on GABA signaling. GABAergic components negatively regulate the immune responses, particularly the T cell-mediated immunity, via their effects on production of pro-inflammatory cytokines and activation of signal pathways, like mitogen-activated protein kinase and nuclear factor-kappaB pathways. These results may indicate that GABAergic components provide a new therapeutic approach for inflammatory and autoimmune diseases, such as experimental autoimmune encephalomyelitis, multiple sclerosis, and inflammatory bowel diseases.
Similar articles
- Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.Prud'homme GJ, Glinka Y, Wang Q.Prud'homme GJ, et al.Autoimmun Rev. 2015 Nov;14(11):1048-56. doi: 10.1016/j.autrev.2015.07.011. Epub 2015 Jul 29.Autoimmun Rev. 2015.PMID:26226414Review.
- Inhibitory role for GABA in autoimmune inflammation.Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L.Bhat R, et al.Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2580-5. doi: 10.1073/pnas.0915139107. Epub 2010 Feb 1.Proc Natl Acad Sci U S A. 2010.PMID:20133656Free PMC article.
- GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.Paul AM, Branton WG, Walsh JG, Polyak MJ, Lu JQ, Baker GB, Power C.Paul AM, et al.Neuroscience. 2014 Jul 25;273:24-38. doi: 10.1016/j.neuroscience.2014.04.037. Epub 2014 May 9.Neuroscience. 2014.PMID:24814730
- Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions.Crowley T, Cryan JF, Downer EJ, O'Leary OF.Crowley T, et al.Brain Behav Immun. 2016 May;54:260-277. doi: 10.1016/j.bbi.2016.02.001. Epub 2016 Feb 3.Brain Behav Immun. 2016.PMID:26851553Review.
- GABA is an effective immunomodulatory molecule.Jin Z, Mendu SK, Birnir B.Jin Z, et al.Amino Acids. 2013 Jul;45(1):87-94. doi: 10.1007/s00726-011-1193-7. Epub 2011 Dec 13.Amino Acids. 2013.PMID:22160261Free PMC article.Review.
Cited by
- Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain-Narrative Review.Kocot-Kępska M, Zajączkowska R, Mika J, Kopsky DJ, Wordliczek J, Dobrogowski J, Przeklasa-Muszyńska A.Kocot-Kępska M, et al.Pharmaceutics. 2021 Mar 26;13(4):450. doi: 10.3390/pharmaceutics13040450.Pharmaceutics. 2021.PMID:33810493Free PMC article.Review.
- Understanding the function of the GABAergic system and its potential role in rheumatoid arthritis.Shan Y, Zhao J, Zheng Y, Guo S, Schrodi SJ, He D.Shan Y, et al.Front Immunol. 2023 Feb 7;14:1114350. doi: 10.3389/fimmu.2023.1114350. eCollection 2023.Front Immunol. 2023.PMID:36825000Free PMC article.Review.
- Unraveling the Mechanism of Xiaochaihu Granules in Alleviating Yeast-Induced Fever Based on Network Analysis and Experimental Validation.Chen X, Wu H, Li P, Peng W, Wang Y, Zhang X, Zhang A, Li J, Meng F, Wang W, Su W.Chen X, et al.Pharmaceuticals (Basel). 2024 Apr 8;17(4):475. doi: 10.3390/ph17040475.Pharmaceuticals (Basel). 2024.PMID:38675434Free PMC article.
- Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.Mincheva G, Gimenez-Garzo C, Izquierdo-Altarejos P, Martinez-Garcia M, Doverskog M, Blackburn TP, Hällgren A, Bäckström T, Llansola M, Felipo V.Mincheva G, et al.CNS Neurosci Ther. 2022 Nov;28(11):1861-1874. doi: 10.1111/cns.13926. Epub 2022 Jul 26.CNS Neurosci Ther. 2022.PMID:35880480Free PMC article.
- Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory and analgesic agent.Gao F, Dai Z, Zhang T, Gu Y, Cai D, Lu M, Zhang Z, Zeng Q, Shang B, Xu B, Lei H.Gao F, et al.RSC Adv. 2022 Oct 20;12(46):30001-30007. doi: 10.1039/d2ra05558a. eCollection 2022 Oct 17.RSC Adv. 2022.PMID:36321084Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials