G-Quadruplexes in DNA Replication: A Problem or a Necessity?
- PMID:27663528
- DOI: 10.1016/j.tig.2016.09.004
G-Quadruplexes in DNA Replication: A Problem or a Necessity?
Abstract
DNA replication is a highly regulated process that ensures the correct duplication of the genome at each cell cycle. A precise cell type-specific temporal program controls the duplication of complex vertebrate genomes in an orderly manner. This program is based on the regulation of both replication origin firing and replication fork progression. G-quadruplexes (G4s), DNA secondary structures displaying noncanonical Watson-Crick base pairing, have recently emerged as key controllers of genome duplication. Here we discuss the various means by which G4s affect this fundamental cellular process.
Keywords: DNA replication; G-quadruplex; genetic and epigenetic instability; helicase; replication origin; specialized polymerase.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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