Mechanisms of diabetes mellitus-induced bone fragility
- PMID:27658727
- DOI: 10.1038/nrendo.2016.153
Mechanisms of diabetes mellitus-induced bone fragility
Abstract
The risk of fragility fractures is increased in patients with either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in T2DM is often normal or even slightly elevated compared with an age-matched control population. However, in both T1DM and T2DM, bone turnover is decreased and the bone material properties and microstructure of bone are altered; the latter particularly so when microvascular complications are present. The pathophysiological mechanisms underlying bone fragility in diabetes mellitus are complex, and include hyperglycaemia, oxidative stress and the accumulation of advanced glycation endproducts that compromise collagen properties, increase marrow adiposity, release inflammatory factors and adipokines from visceral fat, and potentially alter the function of osteocytes. Additional factors including treatment-induced hypoglycaemia, certain antidiabetic medications with a direct effect on bone and mineral metabolism (such as thiazolidinediones), as well as an increased propensity for falls, all contribute to the increased fracture risk in patients with diabetes mellitus.
Similar articles
- Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility.Eller-Vainicher C, Cairoli E, Grassi G, Grassi F, Catalano A, Merlotti D, Falchetti A, Gaudio A, Chiodini I, Gennari L.Eller-Vainicher C, et al.J Diabetes Res. 2020 May 22;2020:7608964. doi: 10.1155/2020/7608964. eCollection 2020.J Diabetes Res. 2020.PMID:32566682Free PMC article.Review.
- Impact of diabetes and its treatments on skeletal diseases.Yan W, Li X.Yan W, et al.Front Med. 2013 Mar;7(1):81-90. doi: 10.1007/s11684-013-0243-9. Epub 2013 Feb 2.Front Med. 2013.PMID:23377889Review.
- [Diabetes increases the risk of fractures].Starup-Linde J, Karahasanovic A, Vestergaard P, Eiken P.Starup-Linde J, et al.Ugeskr Laeger. 2015 Nov 30;177(49):V08150663.Ugeskr Laeger. 2015.PMID:26651553Review.Danish.
- Type 2 diabetes and bone fractures.Moseley KF.Moseley KF.Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):128-35. doi: 10.1097/MED.0b013e328350a6e1.Curr Opin Endocrinol Diabetes Obes. 2012.PMID:22262002Free PMC article.Review.
- Fracture Risk Assessment in Patients With Diabetes Mellitus.Poiana C, Capatina C.Poiana C, et al.J Clin Densitom. 2017 Jul-Sep;20(3):432-443. doi: 10.1016/j.jocd.2017.06.011. Epub 2017 Jul 14.J Clin Densitom. 2017.PMID:28716499Review.
Cited by
- Sclerostin Regulation, Microarchitecture, and Advanced Glycation End-Products in the Bone of Elderly Women With Type 2 Diabetes.Piccoli A, Cannata F, Strollo R, Pedone C, Leanza G, Russo F, Greto V, Isgrò C, Quattrocchi CC, Massaroni C, Silvestri S, Vadalà G, Bisogno T, Denaro V, Pozzilli P, Tang SY, Silva MJ, Conte C, Papalia R, Maccarrone M, Napoli N.Piccoli A, et al.J Bone Miner Res. 2020 Dec;35(12):2415-2422. doi: 10.1002/jbmr.4153. Epub 2020 Oct 2.J Bone Miner Res. 2020.PMID:32777114Free PMC article.
- Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.Zheng HX, Chen J, Zu YX, Wang EZ, Qi SS.Zheng HX, et al.Int J Mol Sci. 2020 Jul 26;21(15):5303. doi: 10.3390/ijms21155303.Int J Mol Sci. 2020.PMID:32722636Free PMC article.
- Causal relationship between glycemic traits and bone mineral density in different age groups and skeletal sites: a Mendelian randomization analysis.Xu Z, Shi Y, Wei C, Li T, Wen J, Du W, Yu Y, Zhu T.Xu Z, et al.J Bone Miner Metab. 2024 Jan;42(1):90-98. doi: 10.1007/s00774-023-01480-5. Epub 2023 Dec 29.J Bone Miner Metab. 2024.PMID:38157037
- Fracture healing research: Recent insights.Steppe L, Megafu M, Tschaffon-Müller MEA, Ignatius A, Haffner-Luntzer M.Steppe L, et al.Bone Rep. 2023 May 19;19:101686. doi: 10.1016/j.bonr.2023.101686. eCollection 2023 Dec.Bone Rep. 2023.PMID:38163010Free PMC article.Review.
- Systematic Review: Are the Elderly With Diabetes Mellitus Type 2 Prone to Fragility Fractures?Papaioannou I, Pantazidou G, Kokkalis Z, Georgopoulos N, Jelastopulu E.Papaioannou I, et al.Cureus. 2021 Apr 16;13(4):e14514. doi: 10.7759/cureus.14514.Cureus. 2021.PMID:34007765Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical