Region-specific roles of the corticotropin-releasing factor-urocortin system in stress
- PMID:27586075
- DOI: 10.1038/nrn.2016.94
Region-specific roles of the corticotropin-releasing factor-urocortin system in stress
Abstract
Dysregulation of the corticotropin-releasing factor (CRF)-urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF-CRF receptor type 1 (CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery and the restoration of homeostasis. Recent findings, however, provide clear evidence that this view is overly simplistic. Instead, a more complex picture has emerged that suggests that there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.
Comment in
- Structural plasticity and reorganisation in chronic pain.Kuner R, Flor H.Kuner R, et al.Nat Rev Neurosci. 2017 Jan 20;18(2):113. doi: 10.1038/nrn.2017.5.Nat Rev Neurosci. 2017.PMID:28704354No abstract available.
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