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Review
.2016 May 27:10:1795-806.
doi: 10.2147/DDDT.S98939. eCollection 2016.

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

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Review

The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

John R Brannon et al. Drug Des Devel Ther..

Abstract

Pathogens deploy an arsenal of virulence factors (VFs) to establish themselves within their infectious niche. The discovery of antimicrobial compounds and their development into therapeutics has made a monumental impact on human and microbial populations. Although humans have used antimicrobials for medicinal and agricultural purposes, microorganism populations have developed and shared resistance mechanisms to persevere in the face of classical antimicrobials. However, a positive substitute is antivirulence therapy; antivirulence therapeutics prevent or interrupt an infection by counteracting a pathogen's VFs. Their application can reduce the use of broad-spectrum antimicrobials and dampen the frequency with which resistant strains emerge. Here, we summarize the contribution of VFs to various acute and chronic infections. In correspondence with this, we provide an overview of the research and development of antivirulence strategies.

Keywords: Escherichia coli; antivirulence therapeutics; biofilms; persister cells; quorum sensing; regulation; virulence factors.

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