2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection

A J Demetris¹, C Bellamy², S G Hübscher³, J O'Leary⁴, P S Randhawa¹, S Feng⁵, D Neil⁶, R B Colvin⁷, G McCaughan⁸, J J Fung⁹, A Del Bello¹⁰, F P Reinholt¹¹, H Haga¹², O Adeyi¹³, A J Czaja¹⁴, T Schiano¹⁵, M I Fiel¹⁶, M L Smith¹⁷, M Sebagh¹⁸, R Y Tanigawa¹⁹, F Yilmaz²⁰, G Alexander²¹, L Baiocchi²², M Balasubramanian²³, I Batal²⁴, A K Bhan⁷, J Bucuvalas²⁵, C T S Cerski²⁶, F Charlotte²⁷, M E de Vera²⁸, M ElMonayeri²⁹, P Fontes¹, E E Furth³⁰, A S H Gouw³¹, S Hafezi-Bakhtiari³², J Hart³³, E Honsova³⁴, W Ismail³⁵, T Itoh³⁶, N C Jhala³⁷, U Khettry³⁸, G B Klintmalm⁴, S Knechtle³⁹, T Koshiba⁴⁰, T Kozlowski⁴¹, C R Lassman⁴², J Lerut⁴³, J Levitsky⁴⁴, L Licini⁴⁵, R Liotta⁴⁶, G Mazariegos⁴⁷, M I Minervini¹, J Misdraji⁷, T Mohanakumar⁴⁸, J Mölne⁴⁹, I Nasser⁵⁰, J Neuberger⁶, M O'Neil⁵¹, O Pappo⁵², L Petrovic⁵³, P Ruiz⁵⁴, Ö Sağol⁵⁵, A Sanchez Fueyo⁵⁶, E Sasatomi⁵⁷, A Shaked⁵⁸, M Shiller⁴, T Shimizu⁵⁹, B Sis⁶⁰, A Sonzogni⁴⁵, H L Stevenson⁶¹, S N Thung¹⁶, G Tisone⁶², A C Tsamandas⁶³, A Wernerson⁶⁴, T Wu⁶⁵, A Zeevi⁶⁶, Y Zen³⁶

Affiliations

¹ University of Pittsburgh Medical Center, Pittsburgh, PA.
² The University of Edinburgh, Edinburgh, Scotland.
³ University of Birmingham, Birmingham, UK.
⁴ Baylor University Medical Center, Dallas, TX.
⁵ University of California San Francisco Medical Center, San Francisco, CA.
⁶ Queen Elizabeth Hospital Birmingham, Birmingham, UK.
⁷ Massachusetts General Hospital, Boston, MA.
⁸ Royal Prince Alfred Hospital, Sydney, Australia.
⁹ Cleveland Clinic, Cleveland, OH.
¹⁰ Chu Toulouse Rangueil, Toulouse, France.
¹¹ Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹² Kyoto University Hospital, Kyoto, Japan.
¹³ University Health Network and University of Toronto, Toronto, Canada.
¹⁴ Mayo Clinic College of Medicine, Rochester, MN.
¹⁵ Mount Sinai Medical Center, New York, NY.
¹⁶ Icahn School of Medicine at Mount Sinai, New York, NY.
¹⁷ Mayo Clinic Health System, Scottsdale, AZ.
¹⁸ AP-HP Hôpital Paul-Brousse, Paris, France.
¹⁹ Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
²⁰ University of Ege, Faculty of Medicine, Izmir, Turkey.
²¹ University of Cambridge, Cambridge, UK.
²² Policlinico Universitario Tor Vergata, Rome, Italy.
²³ Einstein Medical Center, Philadelphia, PA.
²⁴ Columbia University College of Physicians and Surgeons, New York, NY.
²⁵ Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
²⁶ Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
²⁷ Hôpital Pitié-Salpêtrière, Paris, France.
²⁸ Loma Linda University, Loma Linda, CA.
²⁹ Ain Shams University, Wady El-Neel Hospital, Cairo, Egypt.
³⁰ Hospital of the University of Pennsylvania, Philadelphia, PA.
³¹ University Medical Center Groningen, Groningen, the Netherlands.
³² UHN Toronto General Hospital, Toronto, Canada.
³³ University of Chicago Hospitals, Chicago, IL.
³⁴ Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
³⁵ Beni-Suef University, Beni-Suef, Egypt.
³⁶ Kobe University Hospital, Kobe, Japan.
³⁷ Temple University, Philadelphia, PA.
³⁸ Lahey Hospital and Medical Center, Burlington, MA.
³⁹ Duke University Health System, Durham, NC.
⁴⁰ Soma Central Hospital, Soma, Fukushima, Japan.
⁴¹ University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁴² David Geffen School of Medicine at UCLA, Los Angeles, CA.
⁴³ Cliniques Universitaires Saint-Luc, Brussels, Belgium.
⁴⁴ Northwestern University Feinberg School of Medicine, Chicago, IL.
⁴⁵ Pope John XXIII Hospital, Bergamo, Italy.
⁴⁶ Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Palermo, Italy.
⁴⁷ Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA.
⁴⁸ St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ.
⁴⁹ University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
⁵⁰ Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA.
⁵¹ University of Kansas Medical Center, Kansas City, KS.
⁵² Hadassah Medical Center, Jerusalem, Israel.
⁵³ University of Southern California, Los Angeles, CA.
⁵⁴ University of Miami, Miami, FL.
⁵⁵ School of Medicine, Dokuz Eylul University, Izmir, Turkey.
⁵⁶ King's College Hospital, London, UK.
⁵⁷ University of North Carolina School of Medicine, Chapel Hill, NC.
⁵⁸ University of Pennsylvania Health System, Philadelphia, PA.
⁵⁹ Toda Chuo General Hospital, Saitama, Japan.
⁶⁰ University of Alberta Hospital, Edmonton, Canada.
⁶¹ University of Texas Medical Branch, Galveston, TX.
⁶² University of Rome-Tor Vergata, Rome, Italy.
⁶³ University of Patras, Patras, Greece.
⁶⁴ Karolinska University Hospital, Stockholm, Sweden.
⁶⁵ Tulane University School of Medicine, New Orleans, LA.
⁶⁶ University of Pittsburgh, Pittsburgh, PA.

PMID:27273869
DOI: 10.1111/ajt.13909

Free article

2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection

A J Demetris et al. Am J Transplant.2016 Oct.

Free article

.2016 Oct;16(10):2816-2835.

doi: 10.1111/ajt.13909. Epub 2016 Jul 14.

Authors

Affiliations

¹ University of Pittsburgh Medical Center, Pittsburgh, PA.
² The University of Edinburgh, Edinburgh, Scotland.
³ University of Birmingham, Birmingham, UK.
⁴ Baylor University Medical Center, Dallas, TX.
⁵ University of California San Francisco Medical Center, San Francisco, CA.
⁶ Queen Elizabeth Hospital Birmingham, Birmingham, UK.
⁷ Massachusetts General Hospital, Boston, MA.
⁸ Royal Prince Alfred Hospital, Sydney, Australia.
⁹ Cleveland Clinic, Cleveland, OH.
¹⁰ Chu Toulouse Rangueil, Toulouse, France.
¹¹ Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹² Kyoto University Hospital, Kyoto, Japan.
¹³ University Health Network and University of Toronto, Toronto, Canada.
¹⁴ Mayo Clinic College of Medicine, Rochester, MN.
¹⁵ Mount Sinai Medical Center, New York, NY.
¹⁶ Icahn School of Medicine at Mount Sinai, New York, NY.
¹⁷ Mayo Clinic Health System, Scottsdale, AZ.
¹⁸ AP-HP Hôpital Paul-Brousse, Paris, France.
¹⁹ Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
²⁰ University of Ege, Faculty of Medicine, Izmir, Turkey.
²¹ University of Cambridge, Cambridge, UK.
²² Policlinico Universitario Tor Vergata, Rome, Italy.
²³ Einstein Medical Center, Philadelphia, PA.
²⁴ Columbia University College of Physicians and Surgeons, New York, NY.
²⁵ Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
²⁶ Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
²⁷ Hôpital Pitié-Salpêtrière, Paris, France.
²⁸ Loma Linda University, Loma Linda, CA.
²⁹ Ain Shams University, Wady El-Neel Hospital, Cairo, Egypt.
³⁰ Hospital of the University of Pennsylvania, Philadelphia, PA.
³¹ University Medical Center Groningen, Groningen, the Netherlands.
³² UHN Toronto General Hospital, Toronto, Canada.
³³ University of Chicago Hospitals, Chicago, IL.
³⁴ Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
³⁵ Beni-Suef University, Beni-Suef, Egypt.
³⁶ Kobe University Hospital, Kobe, Japan.
³⁷ Temple University, Philadelphia, PA.
³⁸ Lahey Hospital and Medical Center, Burlington, MA.
³⁹ Duke University Health System, Durham, NC.
⁴⁰ Soma Central Hospital, Soma, Fukushima, Japan.
⁴¹ University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁴² David Geffen School of Medicine at UCLA, Los Angeles, CA.
⁴³ Cliniques Universitaires Saint-Luc, Brussels, Belgium.
⁴⁴ Northwestern University Feinberg School of Medicine, Chicago, IL.
⁴⁵ Pope John XXIII Hospital, Bergamo, Italy.
⁴⁶ Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Palermo, Italy.
⁴⁷ Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA.
⁴⁸ St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ.
⁴⁹ University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
⁵⁰ Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA.
⁵¹ University of Kansas Medical Center, Kansas City, KS.
⁵² Hadassah Medical Center, Jerusalem, Israel.
⁵³ University of Southern California, Los Angeles, CA.
⁵⁴ University of Miami, Miami, FL.
⁵⁵ School of Medicine, Dokuz Eylul University, Izmir, Turkey.
⁵⁶ King's College Hospital, London, UK.
⁵⁷ University of North Carolina School of Medicine, Chapel Hill, NC.
⁵⁸ University of Pennsylvania Health System, Philadelphia, PA.
⁵⁹ Toda Chuo General Hospital, Saitama, Japan.
⁶⁰ University of Alberta Hospital, Edmonton, Canada.
⁶¹ University of Texas Medical Branch, Galveston, TX.
⁶² University of Rome-Tor Vergata, Rome, Italy.
⁶³ University of Patras, Patras, Greece.
⁶⁴ Karolinska University Hospital, Stockholm, Sweden.
⁶⁵ Tulane University School of Medicine, New Orleans, LA.
⁶⁶ University of Pittsburgh, Pittsburgh, PA.

PMID:27273869
DOI: 10.1111/ajt.13909

Abstract

The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), and 13th (Vancouver, British Columbia, Canada, October 5-10, 2015) meetings of the Banff Conference on Allograft Pathology. Discussion continued online. The primary goal was to introduce guidelines and consensus criteria for the diagnosis of liver allograft antibody-mediated rejection and provide a comprehensive update of all Banff Schema recommendations. Included are new recommendations for complement component 4d tissue staining and interpretation, staging liver allograft fibrosis, and findings related to immunosuppression minimization. In an effort to create a single reference document, previous unchanged criteria are also included.

Keywords: classification systems: Banff classification; clinical research/practice; guidelines; immunosuppression/immune modulation; liver transplantation/hepatology; rejection: T cell mediated (TCMR); rejection: antibody-mediated (ABMR); tolerance.

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Comment in

Antibody-Mediated Injury to the Transplanted Liver: Receiving the Sages' Wisdom.
O'Grady J.O'Grady J.Am J Transplant. 2016 Oct;16(10):2773-2774. doi: 10.1111/ajt.13954. Epub 2016 Aug 1.Am J Transplant. 2016.PMID:27389047No abstract available.

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2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection

Affiliations

2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection

Authors

Affiliations

Abstract

Comment in

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical