Evaluation of oxidative stress markers in obstructive sleep apnea syndrome and additional antioxidant therapy: a review article
- PMID:27255237
- DOI: 10.1007/s11325-016-1367-3
Evaluation of oxidative stress markers in obstructive sleep apnea syndrome and additional antioxidant therapy: a review article
Abstract
Purpose: The hypoxia and reoxygenation cycles in obstructive sleep apnea syndrome (OSAS) cause a change in the oxidative balance, leading to the formation of reactive oxygen species capable of reacting with other organic molecules impairing their functions. This study aimed to determine the best markers of oxidative stress in OSAS and what better antioxidant agent to be used to treat the disease.
Methods: Searches were conducted in three different databases (PubMed, LILACS, SCIELO), using as descriptors the terms obstructive sleep apnea, oxidative stress, and antioxidant therapy. A total of 120 articles were found but only those considered of interest to the research were selected. Thus, 10 articles were included for further analysis regarding the biomarkers of oxidative stress in OSAS, and 6 articles to evaluate the antioxidant most often used for demonstration of efficacy.
Results: The thioredoxin, malondialdehyde, superoxide dysmutase, and reduced iron were the most commonly used biomarkers and showed a more consistent relationship between increased oxidative stress and OSAS. As antioxidant therapy, vitamin C and N-acetylcysteine (NAC) presented interesting results as a reduction of oxidative stress, which may become an alternative to the complementary treatment of OSAS.
Conclusions: This review's findings agree mostly to measure that the markers of oxidative stress in OSAS may be a contributing aspect to assessment and monitoring of patient, and the antioxidant therapy appears to be beneficial in the treatment of OSAS.
Keywords: Antioxidant therapy; Markers; Obstructive sleep apnea; Oxidative stress.
Similar articles
- Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome.Mancuso M, Bonanni E, LoGerfo A, Orsucci D, Maestri M, Chico L, DiCoscio E, Fabbrini M, Siciliano G, Murri L.Mancuso M, et al.Sleep Med. 2012 Jun;13(6):632-6. doi: 10.1016/j.sleep.2011.10.030. Epub 2012 Apr 23.Sleep Med. 2012.PMID:22534161
- Oxidative stress markers in the blood of persons with different stages of obstructive sleep apnea syndrome.Cofta S, Wysocka E, Piorunek T, Rzymkowska M, Batura-Gabryel H, Torlinski L.Cofta S, et al.J Physiol Pharmacol. 2008 Dec;59 Suppl 6:183-90.J Physiol Pharmacol. 2008.PMID:19218642
- Oxidative and carbonyl stress in patients with obstructive sleep apnea treated with continuous positive airway pressure.Celec P, Hodosy J, Behuliak M, Pálffy R, Gardlík R, Halčák L, Mucska I.Celec P, et al.Sleep Breath. 2012 Jun;16(2):393-8. doi: 10.1007/s11325-011-0510-4. Epub 2011 Mar 26.Sleep Breath. 2012.PMID:21437776
- Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea.Meliante PG, Zoccali F, Cascone F, Di Stefano V, Greco A, de Vincentiis M, Petrella C, Fiore M, Minni A, Barbato C.Meliante PG, et al.Int J Mol Sci. 2023 Mar 13;24(6):5478. doi: 10.3390/ijms24065478.Int J Mol Sci. 2023.PMID:36982552Free PMC article.Review.
- Role of Oxidative Stress in the Occurrence and Development of Cognitive Dysfunction in Patients with Obstructive Sleep Apnea Syndrome.Zhang X, Zhou H, Liu H, Xu P.Zhang X, et al.Mol Neurobiol. 2024 Aug;61(8):5083-5101. doi: 10.1007/s12035-023-03899-3. Epub 2023 Dec 30.Mol Neurobiol. 2024.PMID:38159196Review.
Cited by
- Reactive oxygen species and TNF-α: the interplay between obstructive sleep apnea and Behçet's disease.Le Joncour A, Cacoub P, Marques C, Saadoun D.Le Joncour A, et al.Sleep Breath. 2021 Sep;25(3):1553-1554. doi: 10.1007/s11325-020-02220-z. Epub 2020 Oct 12.Sleep Breath. 2021.PMID:33047240No abstract available.
- Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to Hearing System Impairment.Mastino P, Rosati D, de Soccio G, Romeo M, Pentangelo D, Venarubea S, Fiore M, Meliante PG, Petrella C, Barbato C, Minni A.Mastino P, et al.Antioxidants (Basel). 2023 Jul 15;12(7):1430. doi: 10.3390/antiox12071430.Antioxidants (Basel). 2023.PMID:37507968Free PMC article.Review.
- Mechanisms of cardiovascular disease in obstructive sleep apnoea.Ryan S.Ryan S.J Thorac Dis. 2018 Dec;10(Suppl 34):S4201-S4211. doi: 10.21037/jtd.2018.08.56.J Thorac Dis. 2018.PMID:30687536Free PMC article.Review.
- Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea.Gu X, Yang W, Luo X, Wang X, Tang J, Cai Z.Gu X, et al.Sleep Breath. 2019 Mar;23(1):259-267. doi: 10.1007/s11325-018-1694-7. Epub 2018 Jul 10.Sleep Breath. 2019.PMID:29992456
- Oxidative Stress Markers among Obstructive Sleep Apnea Patients.Stanek A, Brożyna-Tkaczyk K, Myśliński W.Stanek A, et al.Oxid Med Cell Longev. 2021 Jul 19;2021:9681595. doi: 10.1155/2021/9681595. eCollection 2021.Oxid Med Cell Longev. 2021.PMID:34336121Free PMC article.Review.
References
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials