Declining Effectiveness of Herpes Zoster Vaccine in Adults Aged ≥60 Years
- PMID:26908728
- DOI: 10.1093/infdis/jiw047
Declining Effectiveness of Herpes Zoster Vaccine in Adults Aged ≥60 Years
Abstract
Understanding long-term effectiveness of herpes zoster (HZ) vaccine is critical for determining vaccine policy. 176 078 members of Kaiser Permanente ≥60 years vaccinated with HZ vaccine and three matched unvaccinated members were included. Hazard ratios and 95% confidence intervals (CIs) associated with vaccination at each year following vaccination were estimated by Cox regression model. The effectiveness of HZ vaccine decreased from 68.7% (95% CI, 66.3%-70.9%) in the first year to 4.2% (95% CI, -24.0% to 25.9%) in the eighth year. This rapid decline in effectiveness of HZ vaccine suggests that a revaccination strategy may be needed, if feasible.
Keywords: adult vaccination; herpes zoster; shingles; varicella zoster virus.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
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