Review
doi: 10.1016/j.cell.2015.12.056.The Cellular Phase of Alzheimer's Disease
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- PMID:26871627
- DOI: 10.1016/j.cell.2015.12.056
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Review
The Cellular Phase of Alzheimer's Disease
Bart De Strooper et al. Cell..
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Abstract
The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical observations. We review evidence supporting a long, complex cellular phase consisting of feedback and feedforward responses of astrocytes, microglia, and vasculature. The field must incorporate this holistic view and take advantage of advances in single-cell approaches to resolve the critical junctures at which perturbations initially amenable to compensatory feedback transform into irreversible, progressive neurodegeneration.
Copyright © 2016 Elsevier Inc. All rights reserved.
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