doi: 10.1186/s13619-015-0026-7. eCollection 2015.
Stem cell therapy for amyotrophic lateral sclerosis
Affiliations
- PMID:26594318
- PMCID: PMC4653876
- DOI: 10.1186/s13619-015-0026-7
Item in Clipboard
Stem cell therapy for amyotrophic lateral sclerosis
Zhijuan Mao et al. Cell Regen..
Display options
Format
Display options
Format
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has only limited clinical benefits. Stem-cell-based therapy has been intensively and extensively studied as a potential novel treatment strategy for ALS and has been shown to be effective, at least to some extent. In this article, we will review the current state of research on the use of stem cell therapy in the treatment of ALS and discuss the most promising stem cells for the treatment of ALS.
Keywords: Amyotrophic lateral sclerosis; Cell transplantation; Clinical translation; Stem cells.
Similar articles
- Clinical relevance of stem cell therapies in amyotrophic lateral sclerosis.Srivastava AK.Srivastava AK.Neurol India. 2014 May-Jun;62(3):239-48. doi: 10.4103/0028-3886.136895.Neurol India. 2014.PMID:25033844Review.
- Stem cell therapy in amyotrophic lateral sclerosis.Meamar R, Nasr-Esfahani MH, Mousavi SA, Basiri K.Meamar R, et al.J Clin Neurosci. 2013 Dec;20(12):1659-63. doi: 10.1016/j.jocn.2013.04.024. Epub 2013 Oct 19.J Clin Neurosci. 2013.PMID:24148693Review.
- Translational stem cell therapy for amyotrophic lateral sclerosis.Boulis NM, Federici T, Glass JD, Lunn JS, Sakowski SA, Feldman EL.Boulis NM, et al.Nat Rev Neurol. 2011 Dec 13;8(3):172-6. doi: 10.1038/nrneurol.2011.191.Nat Rev Neurol. 2011.PMID:22158518Review.
- Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.Jaiswal MK.Jaiswal MK.Neural Regen Res. 2017 May;12(5):723-736. doi: 10.4103/1673-5374.206635.Neural Regen Res. 2017.PMID:28616022Free PMC article.Review.
- Advances, Challenges, and Perspectives in Translational Stem Cell Therapy for Amyotrophic Lateral Sclerosis.Abati E, Bresolin N, Comi G, Corti S.Abati E, et al.Mol Neurobiol. 2019 Oct;56(10):6703-6715. doi: 10.1007/s12035-019-1554-x. Epub 2019 Mar 26.Mol Neurobiol. 2019.PMID:30911936Review.
Cited by
- Cellular and Noncellular Approaches for Repairing the Damaged Blood-CNS-Barrier in Amyotrophic Lateral Sclerosis.Manora L, Borlongan CV, Garbuzova-Davis S.Manora L, et al.Cells. 2024 Feb 29;13(5):435. doi: 10.3390/cells13050435.Cells. 2024.PMID:38474399Free PMC article.Review.
- Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis.Appelt PA, Comella K, de Souza LAPS, Luvizutto GJ.Appelt PA, et al.Cerebellum Ataxias. 2021 Feb 25;8(1):8. doi: 10.1186/s40673-021-00130-8.Cerebellum Ataxias. 2021.PMID:33632326Free PMC article.Review.
- Safety, Feasibility of Intravenous and Intrathecal Injection of Autologous Bone Marrow Derived Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: An Open Label Phase I Clinical Trial.Nabavi SM, Arab L, Jarooghi N, Bolurieh T, Abbasi F, Mardpour S, Azimyian V, Moeininia F, Maroufizadeh S, Sanjari L, Hosseini SE, Aghdami N.Nabavi SM, et al.Cell J. 2019 Jan;20(4):592-598. doi: 10.22074/cellj.2019.5370. Epub 2018 Aug 1.Cell J. 2019.PMID:30124008Free PMC article.
- Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases.Singh S, Srivastava A, Srivastava P, Dhuriya YK, Pandey A, Kumar D, Rajpurohit CS.Singh S, et al.Front Mol Biosci. 2016 Nov 8;3:72. doi: 10.3389/fmolb.2016.00072. eCollection 2016.Front Mol Biosci. 2016.PMID:27878120Free PMC article.Review.
- Neural Cells for Neurodegenerative Diseases in Clinical Trials.Fan Y, Goh ELK, Chan JKY.Fan Y, et al.Stem Cells Transl Med. 2023 Aug 16;12(8):510-526. doi: 10.1093/stcltm/szad041.Stem Cells Transl Med. 2023.PMID:37487111Free PMC article.Review.
References
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous