Enzyme-Powered Hollow Mesoporous Janus Nanomotors
- PMID:26437378
- DOI: 10.1021/acs.nanolett.5b03100
Enzyme-Powered Hollow Mesoporous Janus Nanomotors
Erratum in
- Correction to Enzyme-Powered Hollow Mesoporous Janus Nanomotors.Ma X, Jannasch A, Albrecht UR, Hahn K, Miguel-López A, Schäffer E, Sánchez S.Ma X, et al.Nano Lett. 2015 Nov 11;15(11):7779. doi: 10.1021/acs.nanolett.5b04318. Epub 2015 Nov 2.Nano Lett. 2015.PMID:26523631No abstract available.
Abstract
The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.
Keywords: Hollow mesoporous silica nanoparticles; Janus particles; enzyme; hybrid motors; nanomotors; optical tweezers.
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