Review
doi: 10.1016/j.conb.2015.09.004. Epub 2015 Sep 29.Tau neurotoxicity and rescue in animal models of human Tauopathies
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- DOI: 10.1016/j.conb.2015.09.004
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Review
Tau neurotoxicity and rescue in animal models of human Tauopathies
Lars Krüger et al. Curr Opin Neurobiol.2016 Feb.
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Abstract
Pathological Tau is a hallmark of various neuronal disorders and spreads in the brain of Alzheimer patients in a well-defined manner. Beside Tau's main function in stabilizing microtubules for axonal transport, a variety of novel functions for neurons and glia have emerged recently. Tau regulates the susceptibility to hyperexcitation and plays a role in neuron-glia contact formation. Studies implicate soluble oligomeric species of Tau, rather than insoluble aggregates, as more detrimental to proper neuronal function. Tau is not exclusively intracellular; instead Tau can be released into the extracellular space. This has led to the hypothesis of a prion-disease like mechanism to explain the stereotypical progression of Tau. Targeting pathological Tau with antibodies or aggregation inhibitors may help to prevent pathology.
Copyright © 2015 Elsevier Ltd. All rights reserved.
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