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Review
.2015 Oct;19(10):50.
doi: 10.1007/s11916-015-0524-x.

Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

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Review

Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

Bjorn Jensen et al. Curr Pain Headache Rep.2015 Oct.

Abstract

Cannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions.

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