Clinical Trial

.2015 Mar 14;6(1):29.

doi: 10.1186/s13287-015-0020-6.

Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)

Rubens C Siqueira^{1 2 3}, Andre Messias⁴, Katharina Messias⁵, Rafael S Arcieri⁶, Milton A Ruiz⁷, Neiglene F Souza⁸, Lia C Martins⁹, Rodrigo Jorge¹⁰

Affiliations

¹ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. rubenssiqueira@terra.com.br.
² Rubens Siqueira Research Center, Sao Jose do Rio Preto, SP, Brazil. rubenssiqueira@terra.com.br.
³ Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil. rubenssiqueira@terra.com.br.
⁴ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. amessias@hotmail.com.
⁵ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. Katharina.Messias@gmail.com.
⁶ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. rsarc@bol.com.br.
⁷ Department of Bone Marrow Transplantation, Beneficencia Portuguesa Hospital, Sao Jose do Rio Preto, SP, Brazil. milruiz@yahoo.com.br.
⁸ Rubens Siqueira Research Center, Sao Jose do Rio Preto, SP, Brazil. Neiglene@hotmail.com.
⁹ Discipline of Biology, Paulista University (UNIP), Sao Jose do Rio Preto, SP, Brazil. liacampanha1@gmail.com.
¹⁰ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. retinausp@hotmail.com.

PMID:25890251
PMCID: PMC4393588
DOI: 10.1186/s13287-015-0020-6

Clinical Trial

Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)

Rubens C Siqueira et al. Stem Cell Res Ther.2015.

.2015 Mar 14;6(1):29.

doi: 10.1186/s13287-015-0020-6.

Authors

Rubens C Siqueira^{1 2 3}, Andre Messias⁴, Katharina Messias⁵, Rafael S Arcieri⁶, Milton A Ruiz⁷, Neiglene F Souza⁸, Lia C Martins⁹, Rodrigo Jorge¹⁰

Affiliations

¹ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. rubenssiqueira@terra.com.br.
² Rubens Siqueira Research Center, Sao Jose do Rio Preto, SP, Brazil. rubenssiqueira@terra.com.br.
³ Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil. rubenssiqueira@terra.com.br.
⁴ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. amessias@hotmail.com.
⁵ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. Katharina.Messias@gmail.com.
⁶ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. rsarc@bol.com.br.
⁷ Department of Bone Marrow Transplantation, Beneficencia Portuguesa Hospital, Sao Jose do Rio Preto, SP, Brazil. milruiz@yahoo.com.br.
⁸ Rubens Siqueira Research Center, Sao Jose do Rio Preto, SP, Brazil. Neiglene@hotmail.com.
⁹ Discipline of Biology, Paulista University (UNIP), Sao Jose do Rio Preto, SP, Brazil. liacampanha1@gmail.com.
¹⁰ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. retinausp@hotmail.com.

PMID:25890251
PMCID: PMC4393588
DOI: 10.1186/s13287-015-0020-6

Abstract

Introduction: Retinitis pigmentosa (RP) is a severe neurodegenerative disease of the retina that can lead to blindness. Even without treatment, a clinical study with the use of stem cells is currently underway and the results are being evaluated. In the present report we assess the vision-related quality of life in patients with RP submitted to intravitreal use of bone marrow-derived stem cells.

Method: The study included 20 patients with RP submitted to intravitreal use of bone marrow-derived stem cells. We evaluate the vision-related quality of life (VRQOL) of patients using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Patients were scheduled to answer the questionnaire before treatment and 3 and 12 months after treatment.

Results: All patients completed the survey as scheduled. There was a statistically significant improvement (P<0.05) in the quality of life of patients 3 months after treatment, whereas by the 12th month there was no statistically significant difference from baseline.

Conclusions: Cell therapy with intravitreal use of bone marrow-derived stem cells can improve the quality of life of patients with RP, although the improvement is lost with time. A larger number of cases will be necessary to evaluate the repercussions of this therapy on the quality of life of these patients.

Trial registration: Clinicaltrials.gov:NCT01560715 . Registered March 19, 2012.

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Figures

**Figure 1**
**Quality of life behaviour of all patients submitted to cell therapy.**

**Figure 2**
**Average quality of life behaviour of all patients submitted to cell therapy.**

See this image and copyright information in PMC

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Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)

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Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)

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