Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
- PMID:2516827
- DOI: 10.1101/gad.3.12b.2083
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
Erratum in
- Genes Dev 1990 Apr;4(4):682
Abstract
An activating transcription factor (ATF)-binding site (consensus sequence 5'-GTGACGTACAG-3') is a promoter element present in a wide variety of viral and cellular genes. The two best-characterized classes of genes that contain ATF sites are E1A-inducible adenoviral genes and cAMP-inducible cellular genes. Here, we report the isolation of eight ATF cDNA clones, each of which is derived from a separate gene. All ATF cDNA clones examined contain a leucine zipper motif and are significantly similar to one another only within this region. The leucine zipper region of ATF proteins is also similar to that of the AP-1/c-jun family of transcription factors, whose DNA-binding site differs from the ATF-binding site at a single position. DNA binding studies reveal two mechanisms for generating further diversity from the ATF proteins. First, some, but not all, combinations of ATF proteins form heterodimers that efficiently bind to DNA. Second, although all ATF proteins bind to the ATF site, their precise interactions with DNA differ from one another, as evidenced by methylation interference analysis. Our results help to explain how a single promoter element, an ATF site, can be present in a wide variety of promoters.
Similar articles
- Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2: interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation.Abdel-Hafiz HA, Chen CY, Marcell T, Kroll DJ, Hoeffler JP.Abdel-Hafiz HA, et al.Oncogene. 1993 May;8(5):1161-74.Oncogene. 1993.PMID:8479741
- Jun and Fos heterodimerize with ATFa, a member of the ATF/CREB family and modulate its transcriptional activity.Chatton B, Bocco JL, Goetz J, Gaire M, Lutz Y, Kedinger C.Chatton B, et al.Oncogene. 1994 Feb;9(2):375-85.Oncogene. 1994.PMID:8290251
- Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells.Gaire M, Chatton B, Kedinger C.Gaire M, et al.Nucleic Acids Res. 1990 Jun 25;18(12):3467-73. doi: 10.1093/nar/18.12.3467.Nucleic Acids Res. 1990.PMID:1694576Free PMC article.
- Behind the Fos and Jun leucine zipper.Kouzarides T, Ziff E.Kouzarides T, et al.Cancer Cells. 1989 Nov;1(3):71-6.Cancer Cells. 1989.PMID:2518283Review.
- Dimers, leucine zippers and DNA-binding domains.Busch SJ, Sassone-Corsi P.Busch SJ, et al.Trends Genet. 1990 Feb;6(2):36-40. doi: 10.1016/0168-9525(90)90071-d.Trends Genet. 1990.PMID:2186528Review.
Cited by
- Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis.Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y.Iwata J, et al.J Biol Chem. 2012 Jan 20;287(4):2353-63. doi: 10.1074/jbc.M111.280974. Epub 2011 Nov 28.J Biol Chem. 2012.PMID:22123828Free PMC article.
- JunB condensation attenuates vascular endothelial damage under hyperglycemic condition.Ren X, Cui Z, Zhang Q, Su Z, Xu W, Wu J, Jiang H.Ren X, et al.J Mol Cell Biol. 2024 Apr 10;15(12):mjad072. doi: 10.1093/jmcb/mjad072.J Mol Cell Biol. 2024.PMID:38140943Free PMC article.
- Light-inducible and constitutively expressed DNA-binding proteins recognizing a plant promoter element with functional relevance in light responsiveness.Weisshaar B, Armstrong GA, Block A, da Costa e Silva O, Hahlbrock K.Weisshaar B, et al.EMBO J. 1991 Jul;10(7):1777-86. doi: 10.1002/j.1460-2075.1991.tb07702.x.EMBO J. 1991.PMID:2050115Free PMC article.
- Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.Hagen G, Müller S, Beato M, Suske G.Hagen G, et al.Nucleic Acids Res. 1992 Nov 11;20(21):5519-25. doi: 10.1093/nar/20.21.5519.Nucleic Acids Res. 1992.PMID:1454515Free PMC article.
- Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase.Sano Y, Akimaru H, Okamura T, Nagao T, Okada M, Ishii S.Sano Y, et al.Mol Biol Cell. 2005 Jun;16(6):2934-46. doi: 10.1091/mbc.e04-11-1008. Epub 2005 Mar 23.Mol Biol Cell. 2005.PMID:15788564Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous