Epstein-barr virus-induced hemophagocytic lymphohistiocytosis
- PMID:24505517
- PMCID: PMC3913132
Epstein-barr virus-induced hemophagocytic lymphohistiocytosis
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is one of the complications of Epstein-Barr virus (EBV) infection. Although the patients who have developed HLH following EBV have normal immune system, there are a few patients with EBV-induced immune deficiency who develop HLH as well. Here, we describe the case of a 10-year-old girl with neurological complications caused by EBV-induced HLH. The patient received rituximab, leading to weakening inflammation associated with EBV infection and suppression of disease through quick treatment.
Keywords: Epstein - Barr virus; Etanercept; Hemophagocytic lymphohistiocytosis; Infectious mononucleosis; Systemic inflammatory response syndrome; X-Linked lymphoproliferative disease.
Similar articles
- A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications.Kawamura Y, Miura H, Matsumoto Y, Uchida H, Kudo K, Hata T, Ito Y, Kimura H, Yoshikawa T.Kawamura Y, et al.BMC Pediatr. 2016 Oct 28;16(1):172. doi: 10.1186/s12887-016-0718-3.BMC Pediatr. 2016.PMID:27793118Free PMC article.
- Epstein-Barr virus-related hemophagocytic lymphohistiocytosis complicated with coronary artery dilation and acute renal injury in a boy with a novel X-linked inhibitor of apoptosis protein (XIAP) variant: a case report.Chen RY, Li XZ, Lin Q, Zhu Y, Shen YY, Xu QY, Zhu XM, Bai ZJ, Li Y.Chen RY, et al.BMC Pediatr. 2020 Oct 2;20(1):456. doi: 10.1186/s12887-020-02359-4.BMC Pediatr. 2020.PMID:33008347Free PMC article.
- Systemic Epstein-Barr Virus-Positive T/NK Lymphoproliferative Diseases WithSH2D1A/XIAP Hypomorphic Gene Variants.Ishimura M, Eguchi K, Shiraishi A, Sonoda M, Azuma Y, Yamamoto H, Imadome KI, Ohga S.Ishimura M, et al.Front Pediatr. 2019 May 21;7:183. doi: 10.3389/fped.2019.00183. eCollection 2019.Front Pediatr. 2019.PMID:31231620Free PMC article.
- Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis.Marsh RA.Marsh RA.Front Immunol. 2018 Jan 8;8:1902. doi: 10.3389/fimmu.2017.01902. eCollection 2017.Front Immunol. 2018.PMID:29358936Free PMC article.Review.
- Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.Imashuku S.Imashuku S.Crit Rev Oncol Hematol. 2002 Dec;44(3):259-72. doi: 10.1016/s1040-8428(02)00117-8.Crit Rev Oncol Hematol. 2002.PMID:12467966Review.
Cited by
- A Case Report of Hemophagocytic Lymphohistiocytosis (HLH) - An Unusual Complication of Dengue Infection.Acharya S, Shukla S, Sontakke T, Vs I, Bagga C, Dronamraju S, Giri A.Acharya S, et al.Cureus. 2022 Jul 1;14(7):e26504. doi: 10.7759/cureus.26504. eCollection 2022 Jul.Cureus. 2022.PMID:35923479Free PMC article.
- Epstein-Barr virus induced acute hepatitis with hyperferritinemia: A rare presentation.Theodory B, Dopp M, Swisher AR, Flores RM, Robb PM.Theodory B, et al.IDCases. 2023 Aug 9;33:e01872. doi: 10.1016/j.idcr.2023.e01872. eCollection 2023.IDCases. 2023.PMID:37609447Free PMC article.
- Epstein-Barr Acute Viral Hepatitis With Hyperferritinemia Presents as Obstructive Cholangitis.Trivedi D, Szinte J, Hasan S, Shah SK, Saleem S.Trivedi D, et al.Cureus. 2024 Feb 21;16(2):e54614. doi: 10.7759/cureus.54614. eCollection 2024 Feb.Cureus. 2024.PMID:38524009Free PMC article.
- Navigating Complexity: A Case Study on Hemophagocytic Lymphohistiocytosis Diagnosis and Management Challenges.Nguyen J, Tun N, Burley N, Bolos D.Nguyen J, et al.Cureus. 2024 May 4;16(5):e59628. doi: 10.7759/cureus.59628. eCollection 2024 May.Cureus. 2024.PMID:38707754Free PMC article.
- Macrophage activation syndrome in a patient with systemic lupus erythematosus (SLE) and dual viremia.Awasthi S, Upreti S.Awasthi S, et al.J Community Hosp Intern Med Perspect. 2020 Sep 3;10(5):470-474. doi: 10.1080/20009666.2020.1787811.J Community Hosp Intern Med Perspect. 2020.PMID:33235686Free PMC article.
References
- Ohga S, Nomura A, Takada H, Hara T. Immunological aspects of Epstein-Barr virus infection. Crit Rev Oncol Hematol. 2002;44:203–215. - PubMed
- Henter JI, Horne AC, Arico M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. PediatrBloodCancer. 2007;48:124–131. - PubMed
- Imashuku S. Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. CritRevOncolHematol. 2002;44:259–2722. - PubMed
- Henter JI. Hemophagocytic lymphohistiocytosis (HLH): symptoms, signs and diagnosis of a rapidly fatal childhood disease. 2004. Available at:www.histio.org/site/apps/nl/content2.asp?c_kiKTL4PQLvF&b_1850031&ct_2592057. AccessedJanuary 25, 2007.
- Manual of Pediatric Hematology and Oncology. doi: 10.1016/B978-0-12-375154-6.00001-X. Copyright r 2011 Elsevier Inc. All rights reserved. - DOI
Publication types
Related information
LinkOut - more resources
Full Text Sources