Comment
doi: 10.1073/pnas.1323183111. Epub 2014 Jan 16.Microbial metabolites control gut inflammatory responses
Affiliations
- PMID:24434557
- PMCID: PMC3926042
- DOI: 10.1073/pnas.1323183111
Item in Clipboard
Comment
Microbial metabolites control gut inflammatory responses
Nicholas Arpaia et al. Proc Natl Acad Sci U S A..
Display options
Format
Display options
Format
No abstract available
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Multiple bacterial species and microbial metabolites shape immunity in the intestines. (A) Colonization by SFB or delivery of bacterial-derived ATP promotes Th17 induction by unknown and indirect mechanisms involving DCs. (B)Clostridia species, via production of SCFA, promote the proliferation (i) and de novo induction (ii) of Treg cells in the colonic lamina propria via distinct mechanisms. (C) HDAC inhibitory activity of n-butyrate suppresses proinflammatory cytokine production by intestinal macrophages (MΦ).
Comment on
- The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.Chang PV, Hao L, Offermanns S, Medzhitov R.Chang PV, et al.Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2247-52. doi: 10.1073/pnas.1322269111. Epub 2014 Jan 3.Proc Natl Acad Sci U S A. 2014.PMID:24390544Free PMC article.
Similar articles
- The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.Chang PV, Hao L, Offermanns S, Medzhitov R.Chang PV, et al.Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2247-52. doi: 10.1073/pnas.1322269111. Epub 2014 Jan 3.Proc Natl Acad Sci U S A. 2014.PMID:24390544Free PMC article.
- Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation.Corfe BM.Corfe BM.Mol Biosyst. 2012 Jun;8(6):1609-12. doi: 10.1039/c2mb25028d. Epub 2012 Mar 23.Mol Biosyst. 2012.PMID:22446977
- Cell death, it always matters.Comalada M, Serrat N, Xaus J.Comalada M, et al.J Leukoc Biol. 2010 Dec;88(6):1063-4; author reply 1065-6. doi: 10.1189/jlb.0710401.J Leukoc Biol. 2010.PMID:21123293No abstract available.
- The role of butyrate, a histone deacetylase inhibitor in diabetes mellitus: experimental evidence for therapeutic intervention.Khan S, Jena G.Khan S, et al.Epigenomics. 2015;7(4):669-80. doi: 10.2217/epi.15.20.Epigenomics. 2015.PMID:26111036Review.
- Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?Bourassa MW, Alim I, Bultman SJ, Ratan RR.Bourassa MW, et al.Neurosci Lett. 2016 Jun 20;625:56-63. doi: 10.1016/j.neulet.2016.02.009. Epub 2016 Feb 8.Neurosci Lett. 2016.PMID:26868600Free PMC article.Review.
Cited by
- Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS.Chambers ES, et al.Gut. 2019 Aug;68(8):1430-1438. doi: 10.1136/gutjnl-2019-318424. Epub 2019 Apr 10.Gut. 2019.PMID:30971437Free PMC article.Clinical Trial.
- Responses in colonic microbial community and gene expression of pigs to a long-term high resistant starch diet.Sun Y, Zhou L, Fang L, Su Y, Zhu W.Sun Y, et al.Front Microbiol. 2015 Aug 25;6:877. doi: 10.3389/fmicb.2015.00877. eCollection 2015.Front Microbiol. 2015.PMID:26379652Free PMC article.
- The evolution of the host microbiome as an ecosystem on a leash.Foster KR, Schluter J, Coyte KZ, Rakoff-Nahoum S.Foster KR, et al.Nature. 2017 Aug 2;548(7665):43-51. doi: 10.1038/nature23292.Nature. 2017.PMID:28770836Free PMC article.
- Effects of milk-derived bioactive peptide VPP on diarrhea of pre-weaning calves.Zong X, Gao Y, Du Y, Hou J, Yang L, Xu Q.Zong X, et al.Front Vet Sci. 2023 Mar 29;10:1154197. doi: 10.3389/fvets.2023.1154197. eCollection 2023.Front Vet Sci. 2023.PMID:37065247Free PMC article.
- Microbiota-assisted iron uptake promotes immune tolerance in the intestine.Zhu L, Li G, Liang Z, Qi T, Deng K, Yu J, Peng Y, Zheng J, Song Y, Chang X.Zhu L, et al.Nat Commun. 2023 May 15;14(1):2790. doi: 10.1038/s41467-023-38444-2.Nat Commun. 2023.PMID:37188703Free PMC article.
References
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources