Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

American Chemical Society full text link American Chemical Society Free PMC article
Full text links

Actions

.2014 Jan 17;16(2):456-9.
doi: 10.1021/ol4033418. Epub 2013 Dec 16.

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15

Affiliations

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15

Xiachang Wang et al. Org Lett..

Abstract

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

PubMed Disclaimer

Conflict of interest statement

The authors declare the following competing financial interest: J.S.T. is a co-founder of Centrose (Madison, WI, USA).

Figures

Figure 1
Figure 1
Ruthmycin (1) and representative naturally-occurring frenolicin analogs.
Figure 2
Figure 2
COSY, key HMBC and ROESY correlations of ruthmycin (1).
Figure 3
Figure 3
Experimental and theoretical ECD spectra of ruthmycin (1).
Figure 4
Figure 4
The structure of hebarone, a metabolite of the sea hare-associated fungusTorula herbarum.
See this image and copyright information in PMC

References

    1. Brimble MA, Duncalf LJ, Nairn MR. Nat Prod Rep. 1999;16:267–281. - PubMed
    1. Ellestad GA, Kunstmann MP, Whaley HA, Patterson EL. J Am Chem Soc. 1968;90:1325–1332. - PubMed
    2. Iwai Y, Kora A, Takahashi Y, Hayashi T, Awaya J, Masuma R, Oiwa R, Omura S. J Antibiot. 1978;31:959–965. - PubMed
    3. Hara M, Soga S, Shono K, Eishima J, Mizukami T. J Antibiot. 2001;54:182–186. - PubMed
    4. Salaski EJ, Krishnamurthy G, Ding WD, Yu K, Insaf SS, Eid C, Shim J, Levin JI, Tabei K, Toral-Barza L, Zhang WG, McDonald LA, Honores E, Hanna C, Yamashita A, Johnson B, Li Z, Laakso L, Powell D, Mansour TS. J Med Chem. 2009;52:2181–2184. - PubMed
    1. Shaaban KA, Wang X, Elshahawi SI, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. J Nat Prod. 2013;76:1619–1626. - PMC - PubMed
    2. Shaaban KA, Singh S, Elshahawi SI, Wang X, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JSJ. Antibiot. 2013 doi: 10.1038/ja.2013.113. - DOI - PMC - PubMed
    3. Shaaban KA, Singh S, Elshahawi SI, Wang X, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Nat Prod Res. 2013 doi: 10.1080/14786419.2013.855932. - DOI - PMC - PubMed
    4. Wang X, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Zhang Y, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. J Nat Prod. 2013;76:1441–1447. - PMC - PubMed
    5. YouTube, Web. University of Kentucky Research Communications; Nov 6, 2013.http://www.youtube.com/watch?v=VglEEjMviVA.
    1. Zhang Y, Wang X, Sunkara M, Ye Q, Ponomareva LV, She QB, Morris AJ, Thorson JS. Org Lett. 2013;15:5566–5569. - PMC - PubMed
    1. Laatsch H. AntiBase. Wiley-VCH; Weinheim, Germany: 2012.

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full text links
American Chemical Society full text link American Chemical Society Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2026 Movatter.jp