Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Elsevier Science full text link Elsevier Science Free PMC article
Full text links

Actions

Share

.2014 Jan 3:48:124-8.
doi: 10.1016/j.pnpbp.2013.09.010. Epub 2013 Sep 25.

A preliminary longitudinal volumetric MRI study of amygdala and hippocampal volumes in autism

Affiliations

A preliminary longitudinal volumetric MRI study of amygdala and hippocampal volumes in autism

Naama Barnea-Goraly et al. Prog Neuropsychopharmacol Biol Psychiatry..

Abstract

Background: Previous studies suggest that amygdala volume, when compared with healthy controls, is increased in young children with autism, is unchanged in cohorts of older youth, and is smaller in adults. Hippocampal volume, however, does not appear to have age-related changes, and it is unclear whether individuals with autism have volumetric differences in this structure. The goal of this pilot investigation is to characterize the developmental trajectories of the amygdala and hippocampus in children with autism between the ages of 8 and 14years and to examine clinical correlates of volume change.

Methods: Twenty-three children with autism and 23 controls between the ages of 8 and 12 underwent a magnetic resonance imaging procedure of the brain (T1-weighted) at two time points. Nine children with autism and 14 controls had good quality scans from both time points; however, all usable scans from all subjects (15 children with autism and 22 controls) were included in a mixed effect analysis. Regression models were used to estimate group differences in amygdala and hippocampal volumes. Changes in amygdala and hippocampal volumes (Time 2-Time 1) were correlated with clinical severity measures.

Results: Amygdala volume changes with time were similar between the two groups. Within the autism group, right amygdala volume change was correlated with the ability to establish appropriate eye contact. Right hippocampal volume was significantly increased in the autism group when compared with controls. Differences in right hippocampal volume change with time between the two groups approached significance.

Conclusion: This study provides preliminary evidence of normalization of amygdala volumes in late childhood and adolescence. It also suggests that hippocampal volumetric differences may exist in autism in late childhood and adolescence.

Keywords: Amygdala; Autism; Autism Diagnostic Interview (ADI); Autism Diagnostic Observation Schedule (ADOS); Autism Spectrum Disorders (ASD); Full-scale IQ (FSIQ); Hippocampus; Socioeconomic status (SES); Total Brain volume (TBV).

© 2013.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A: Left, right, and total amygdala volumes across ages 8-16 for both autism and healthy control groups, individual volume change between the two time points as well as the general trajectories are shown (solid lines – controls, dashed lines – autism).B: Left, right, and total hippocampal volumes across ages 8-16 for both autism and healthy control groups, individual volume change between the two time points as well as the general trajectories are shown (solid lines – controls, dashed lines – autism).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adams RB Jr., Franklin RG Jr., et al. (2011). “Amygdala responses to averted vs direct gaze fear vary as a function of presentation speed.” Soc Cogn Affect Neurosci. - PMC - PubMed
    1. Amaral DG, Bauman MD, et al. (2003). “The amygdala: is it an essential component of the neural network for social cognition?” Neuropsychologia 41(4): 517–522. - PubMed
    1. Antenor-Dorsey JA, Hershey T, et al. (2013). “White matter integrity and executive abilities in individuals with phenylketonuria.” Mol Genet Metab 109(2): 125–131. - PMC - PubMed
    1. Asya Karchemskiy AG, Howe Meghan, Adleman Nancy, Simeonova Diana I B.S Dylan Alegria, Reiss Allan, Chang Kiki, (accepted for publication ). “Amygdalar Volume in Youth at High Risk for Development of Bipolar Disorder.” Psychiatry Research - Neuroimaging. - PMC - PubMed
    1. Aylward EH, Minshew NJ, et al. (1999). “MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults.” Neurology 53(9): 2145–2150. - PubMed

MeSH terms

Grants and funding

LinkOut - more resources

Full text links
Elsevier Science full text link Elsevier Science Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp