Review
doi: 10.1016/j.mib.2013.08.001. Epub 2013 Aug 23.Coprophilous fungi: antibiotic discovery and functions in an underexplored arena of microbial defensive mutualism
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- DOI: 10.1016/j.mib.2013.08.001
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Review
Coprophilous fungi: antibiotic discovery and functions in an underexplored arena of microbial defensive mutualism
Gerald F Bills et al. Curr Opin Microbiol.2013 Oct.
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Abstract
Microbial antibiotics can mediate mutualisms and interorganism communications. Herbivorous animal dung offers opportunities for discovery of new antibiotics from microbial communities that compete for a nutrient-rich, ephemeral resource. Distinct lineages form a specialized community of coprophilous (dung-colonizing) fungi. Bacteria, protists, invertebrates, the mammalian digestive system, and other fungi can pose challenges to their fitness in the dung environment. The well-characterized diversity of dung fungi offers accessible systems for dissecting the function of antibiotics and for exploring fungal genomes for new antibiotics. Their potential for antibiotic discovery is evidenced by a high frequency of antifungal antibiotics and bioactive secondary metabolites from limited prior efforts and from mapping biosynthetic pathways in the genomes of the coprophilous fungi Podospora anserina and Sordaria macrospora.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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