Review
doi: 10.1111/imr.12038.CD4(+) T-cell subsets in transplantation
Affiliations
- PMID:23405905
- DOI: 10.1111/imr.12038
Item in Clipboard
Review
CD4(+) T-cell subsets in transplantation
Zhongmin Liu et al. Immunol Rev.2013 Mar.
Display options
Format
Display options
Format
Abstract
The identification of T-helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD4(+) T cells has extended the Th1/Th2 paradigm in the adaptive immunity. In the past decade, many studies in animal models and clinical transplantation have demonstrated that interleukin-17 (IL-17) is involved in allograft rejection. It appears that Th17 cells together with Th1 and Th2 cells play an important role in mediating allograft rejection. Here, we summarize our current knowledge on the contribution of Th1, Th2, Th9, Th17, Th22, and follicular T-helper (Tfh) cells in allograft rejection. We also discuss the regulation of CD4(+) T-cell subsets by CD4(+) Foxp3(+) regulatory T cells (Tregs) in the context of transplantation tolerance.
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Similar articles
- T helper subsets & regulatory T cells: rethinking the paradigm in the clinical context of solid organ transplantation.Askar M.Askar M.Int J Immunogenet. 2014 Jun;41(3):185-94. doi: 10.1111/iji.12106. Epub 2014 Feb 3.Int J Immunogenet. 2014.PMID:24495112Review.
- IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction.Prochazkova J, Pokorna K, Holan V.Prochazkova J, et al.Immunobiology. 2012 Jan;217(1):74-82. doi: 10.1016/j.imbio.2011.07.032. Epub 2011 Aug 5.Immunobiology. 2012.PMID:21903294
- Alloantigen specific T regulatory cells in transplant tolerance.Hall BM, Tran G, Hodgkinson SJ.Hall BM, et al.Int Immunopharmacol. 2009 May;9(5):570-4. doi: 10.1016/j.intimp.2009.01.016. Epub 2009 Jan 29.Int Immunopharmacol. 2009.PMID:19539571Review.
- Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice.Zhang D, Sanchez-Fueyo A, Kawamoto K, Alexopoulos SP, Zhang W, Zheng XX.Zhang D, et al.Cytokine. 2010 Sep;51(3):311-9. doi: 10.1016/j.cyto.2010.06.007. Epub 2010 Jul 2.Cytokine. 2010.PMID:20598563
- Th1/Th2/Th17/Treg expression in cultured PBMCs with antiphospholipid antibodies.Xiao J, Zhu F, Liu X, Xiong J.Xiao J, et al.Mol Med Rep. 2012 Nov;6(5):1035-9. doi: 10.3892/mmr.2012.1055. Epub 2012 Aug 30.Mol Med Rep. 2012.PMID:22941119
Cited by
- Role of the immune system in liver transplantation and its implications for therapeutic interventions.Chen G, Hu X, Huang Y, Xiang X, Pan S, Chen R, Xu X.Chen G, et al.MedComm (2020). 2023 Dec 13;4(6):e444. doi: 10.1002/mco2.444. eCollection 2023 Dec.MedComm (2020). 2023.PMID:38098611Free PMC article.Review.
- The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome.Thieme CJ, Weist BJD, Mueskes A, Roch T, Stervbo U, Rosiewicz K, Wehler P, Stein M, Nickel P, Kurtz A, Lachmann N, Choi M, Schmueck-Henneresse M, Westhoff TH, Reinke P, Babel N.Thieme CJ, et al.Sci Rep. 2019 Dec 13;9(1):19037. doi: 10.1038/s41598-019-55442-x.Sci Rep. 2019.PMID:31836826Free PMC article.
- Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy.Hong S, Banchereau R, Maslow BL, Guerra MM, Cardenas J, Baisch J, Branch DW, Porter TF, Sawitzke A, Laskin CA, Buyon JP, Merrill J, Sammaritano LR, Petri M, Gatewood E, Cepika AM, Ohouo M, Obermoser G, Anguiano E, Kim TW, Nulsen J, Nehar-Belaid D, Blankenship D, Turner J, Banchereau J, Salmon JE, Pascual V.Hong S, et al.J Exp Med. 2019 May 6;216(5):1154-1169. doi: 10.1084/jem.20190185. Epub 2019 Apr 8.J Exp Med. 2019.PMID:30962246Free PMC article.
- Mettl14-mediated m6A modification enhances the function of Foxp3+ regulatory T cells and promotes allograft acceptance.Liu Y, Yuan Y, Zhou Z, Cui Y, Teng Y, Huang H, Yuan H, Zhang Y, Yang L, Zhao G.Liu Y, et al.Front Immunol. 2022 Oct 19;13:1022015. doi: 10.3389/fimmu.2022.1022015. eCollection 2022.Front Immunol. 2022.PMID:36341394Free PMC article.
- Insight on immune cells in rejection and infection postlung transplant.Liao M, Wang C, Zhang M, Qiao K.Liao M, et al.Immun Inflamm Dis. 2023 Jul;11(7):e868. doi: 10.1002/iid3.868.Immun Inflamm Dis. 2023.PMID:37506156Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous