Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Actions

Share

.2013 Feb;29(2):194-6.

[Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma]

[Article in Chinese]
Affiliations
  • PMID:23388341

[Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma]

[Article in Chinese]
Shiping Liao et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi.2013 Feb.

Abstract

Objective: To study the expressions and clinical significance of vasculogenic mimicry (VM) and the related protein Mig-7 and MMP-2 in gastric carcinoma.

Methods: We observed the expressions of CD34, Mig-7 and MMP-2 in 110 patients with gastric carcinoma using immunohistochemistry, VM was determined by CD34/PAS double staining, and analyzed their correlations with the clinical and pathological characteristics of the patients.

Results: In the 110 patients with gastric carcinoma, 35(31.82%) were found positive for VM expression, and it was correlated with the pathological degree and lymph node metastasis (P<0.05), that was, the positive rate of VM in the poorly-differentiated tissues (34%) was higher than that in the well-differentiated tissues (10%), and it was also higher in the lymph node metastasis than that in the non-lymph node metastasis. The expression of Mig-7 was found in 104 out of the 110 cases of gastric carcinoma, with a positive rate of 94.54%. The high expression of Mig-7 was related to lymph node metastasis (P<0.05). The expression rates of Mig-7 and MMP-2 were higher in the VM-positive group than in the VM-negative group (P<0.05). The average survival time and median survival time of the VM-positive group were shorter than those of the VM-negative group (P<0.05).

Conclusion: The presence of VM in gastric carcinoma tissues is proved. The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

MeSH terms

Substances

Related information

LinkOut - more resources

Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp