Prepulse inhibition in psychiatric disorders--apart from schizophrenia
- PMID:23287742
- DOI: 10.1016/j.jpsychires.2012.11.018
Prepulse inhibition in psychiatric disorders--apart from schizophrenia
Abstract
Prepulse inhibition (PPI) is a robust operational measure of sensorimotor gating. In schizophrenic patients PPI is deficient. The aim of our review was to investigate the state of science regarding PPI and psychiatric disorders aside from schizophrenia. We used the online database PubMed in order to search for original published reports on PPI studies. The terms "prepulse inhibition", "sensorimotor gating", "blink recovery", and "blink reflex excitability" have been combined with the names of psychiatric disorders. We found that PPI is deficient in obsessive compulsive disorder (OCD) and Gilles de la Tourette's syndrome (GTS). In bipolar disorder dysfunctional PPI seems to be rather state dependent. Studies on depression and attention deficit/hyperactivity disorder (ADHD) consistently report no alterations. Evidence regarding sensorimotor gating in anxiety, autism, fragile X syndrome, posttraumatic stress disorder (PTSD), substance disorders, and Huntington's disease is still poor. There is a strong need for further studies on PPI in psychiatric disorders. PPI is highly applicable for translational research and might also be a very useful tool to investigate the mode of action of innovative, neuro-modulative techniques. Future PPI studies should control for influencing variables such as smoking, sex, or medication.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
- [Prepulse inhibition of the startle response/reflex in neuropsychiatric disorders].García-Sánchez F, Martínez-Gras I, Rodríguez-Jiménez R, Rubio G.García-Sánchez F, et al.Rev Neurol. 2011 Oct 1;53(7):422-32.Rev Neurol. 2011.PMID:21948013Review.Spanish.
- Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies.Braff DL, Geyer MA, Swerdlow NR.Braff DL, et al.Psychopharmacology (Berl). 2001 Jul;156(2-3):234-58. doi: 10.1007/s002130100810.Psychopharmacology (Berl). 2001.PMID:11549226Review.
- Top-down modulation of prepulse inhibition of the startle reflex in humans and rats.Li L, Du Y, Li N, Wu X, Wu Y.Li L, et al.Neurosci Biobehav Rev. 2009 Sep;33(8):1157-67. doi: 10.1016/j.neubiorev.2009.02.001. Epub 2009 Feb 11.Neurosci Biobehav Rev. 2009.PMID:19747594Review.
- An investigation of prepulse inhibition in pediatric bipolar disorder.Rich BA, Vinton D, Grillon C, Bhangoo RK, Leibenluft E.Rich BA, et al.Bipolar Disord. 2005 Apr;7(2):198-203. doi: 10.1111/j.1399-5618.2005.00183.x.Bipolar Disord. 2005.PMID:15762862
- Sensory and sensorimotor gating in adult attention-deficit/hyperactivity disorder (ADHD).Holstein DH, Vollenweider FX, Geyer MA, Csomor PA, Belser N, Eich D.Holstein DH, et al.Psychiatry Res. 2013 Jan 30;205(1-2):117-26. doi: 10.1016/j.psychres.2012.08.013. Epub 2012 Sep 25.Psychiatry Res. 2013.PMID:23017654
Cited by
- Revisiting the association between hypnotisability and blink rate.Di Gruttola F, Orsini P, Carboncini MC, Rossi B, Santarcangelo EL.Di Gruttola F, et al.Exp Brain Res. 2014 Dec;232(12):3763-9. doi: 10.1007/s00221-014-4073-z. Epub 2014 Aug 20.Exp Brain Res. 2014.PMID:25138913
- Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection.Ronca SE, Smith J, Koma T, Miller MM, Yun N, Dineley KT, Paessler S.Ronca SE, et al.Front Microbiol. 2017 Feb 7;8:188. doi: 10.3389/fmicb.2017.00188. eCollection 2017.Front Microbiol. 2017.PMID:28223982Free PMC article.
- Sensory Gating in Neurodevelopmental Disorders: A Scoping Review.Schulz SE, Luszawski M, Hannah KE, Stevenson RA.Schulz SE, et al.Res Child Adolesc Psychopathol. 2023 Jul;51(7):1005-1019. doi: 10.1007/s10802-023-01058-9. Epub 2023 Apr 4.Res Child Adolesc Psychopathol. 2023.PMID:37014483
- Is prepulse modification altered by continuous theta burst stimulation? DAT1 genotype and motor threshold interact on prepulse modification following brain stimulation.Notzon S, Vennewald N, Gajewska A, Klahn AL, Diemer J, Winter B, Fohrbeck I, Arolt V, Pauli P, Domschke K, Zwanzger P.Notzon S, et al.Eur Arch Psychiatry Clin Neurosci. 2017 Dec;267(8):767-779. doi: 10.1007/s00406-017-0786-x. Epub 2017 Mar 24.Eur Arch Psychiatry Clin Neurosci. 2017.PMID:28337537
- Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics.Nani JV, Lee RS, Yonamine CM, Sant'Anna OA, Juliano MA, Gadelha A, Mari JJ, Hayashi MAF.Nani JV, et al.Sci Rep. 2020 Oct 28;10(1):18513. doi: 10.1038/s41598-020-75616-2.Sci Rep. 2020.PMID:33116174Free PMC article.
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical