Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder
- PMID:23123360
- PMCID: PMC3522768
- DOI: 10.1016/j.pnpbp.2012.10.019
Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder
Abstract
Background: The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms.
Methods: Mothers and teachers completed a validated DSM-IV-referenced rating scale for ADHD and ASD symptoms in 118 children with ASD.
Results: Analyses indicated that children with at least one copy of the S or L(G) allele obtained significantly more severe maternal ratings of hyperactivity (p=0.001; ηp(2)=0.097) and impulsivity (p=0.027; ηp(2)=0.044) but not inattention (p=0.061; ηp(2)=0.032), controlling for ASD severity, than children homozygous for the L(A) allele. Conversely, mothers' ratings indicated that children with L(A)/L(A) genotype had more severe ASD social deficits than S or L(G) allele carriers (p=0.003; ηp(2)=0.081), controlling for ADHD symptom severity. Teachers' ratings though consistent with mothers' ratings of hyperactivity and social deficits were marginally significant (p=0.07/p=0.09). There was some evidence that the magnitude of parent-teacher agreement regarding symptom severity varied as a function of the child's genotype.
Conclusion: The 5-HTTLPR/rs25531 polymorphism or its correlates may modulate severity of ADHD and ASD symptoms in children with ASD, but in different ways. These tentative, hypothesis-generating findings require replication with larger independent samples.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
- Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder.Gadow KD, Pinsonneault JK, Perlman G, Sadee W.Gadow KD, et al.Res Dev Disabil. 2014 Jul;35(7):1658-65. doi: 10.1016/j.ridd.2014.04.007. Epub 2014 Apr 26.Res Dev Disabil. 2014.PMID:24780147Free PMC article.
- Perinatal risk factors interacting with catechol O-methyltransferase and the serotonin transporter gene predict ASD symptoms in children with ADHD.Nijmeijer JS, Hartman CA, Rommelse NN, Altink ME, Buschgens CJ, Fliers EA, Franke B, Minderaa RB, Ormel J, Sergeant JA, Verhulst FC, Buitelaar JK, Hoekstra PJ.Nijmeijer JS, et al.J Child Psychol Psychiatry. 2010 Nov;51(11):1242-50. doi: 10.1111/j.1469-7610.2010.02277.x. Epub 2010 Sep 24.J Child Psychol Psychiatry. 2010.PMID:20868372Free PMC article.
- Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder.Gadow KD, Devincent CJ, Olvet DM, Pisarevskaya V, Hatchwell E.Gadow KD, et al.Eur J Neurosci. 2010 Sep;32(6):1058-65. doi: 10.1111/j.1460-9568.2010.07382.x. Epub 2010 Aug 22.Eur J Neurosci. 2010.PMID:20731709
- Attention-deficit/Hyperactivity Disorder in the context of Autism spectrum disorders.Murray MJ.Murray MJ.Curr Psychiatry Rep. 2010 Oct;12(5):382-8. doi: 10.1007/s11920-010-0145-3.Curr Psychiatry Rep. 2010.PMID:20694583Review.
- Infant regulatory function acts as a protective factor for later traits of autism spectrum disorder and attention deficit/hyperactivity disorder but not callous unemotional traits.Bedford R, Gliga T, Hendry A, Jones EJH, Pasco G, Charman T, Johnson MH, Pickles A; BASIS Team.Bedford R, et al.J Neurodev Disord. 2019 Jul 18;11(1):14. doi: 10.1186/s11689-019-9274-0.J Neurodev Disord. 2019.PMID:31351456Free PMC article.Review.
Cited by
- Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers.Baptista J, Belsky J, Mesquita A, Soares I.Baptista J, et al.Eur Child Adolesc Psychiatry. 2017 Mar;26(3):303-313. doi: 10.1007/s00787-016-0890-x. Epub 2016 Jul 18.Eur Child Adolesc Psychiatry. 2017.PMID:27430630
- A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders.Rose'meyer R.Rose'meyer R.Mol Autism. 2013 Oct 8;4(1):37. doi: 10.1186/2040-2392-4-37.Mol Autism. 2013.PMID:24103554Free PMC article.
- Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder.Gadow KD, Pinsonneault JK, Perlman G, Sadee W.Gadow KD, et al.Res Dev Disabil. 2014 Jul;35(7):1658-65. doi: 10.1016/j.ridd.2014.04.007. Epub 2014 Apr 26.Res Dev Disabil. 2014.PMID:24780147Free PMC article.
- Neuroinflammation as a risk factor for attention deficit hyperactivity disorder.Dunn GA, Nigg JT, Sullivan EL.Dunn GA, et al.Pharmacol Biochem Behav. 2019 Jul;182:22-34. doi: 10.1016/j.pbb.2019.05.005. Epub 2019 May 16.Pharmacol Biochem Behav. 2019.PMID:31103523Free PMC article.Review.
- Risperidone added to parent training and stimulant medication: effects on attention-deficit/hyperactivity disorder, oppositional defiant disorder, conduct disorder, and peer aggression.Gadow KD, Arnold LE, Molina BS, Findling RL, Bukstein OG, Brown NV, McNamara NK, Rundberg-Rivera EV, Li X, Kipp HL, Schneider J, Farmer CA, Baker JL, Sprafkin J, Rice RR Jr, Bangalore SS, Butter EM, Buchan-Page KA, Hurt EA, Austin AB, Grondhuis SN, Aman MG.Gadow KD, et al.J Am Acad Child Adolesc Psychiatry. 2014 Sep;53(9):948-959.e1. doi: 10.1016/j.jaac.2014.05.008. Epub 2014 Jun 12.J Am Acad Child Adolesc Psychiatry. 2014.PMID:25151418Free PMC article.Clinical Trial.
References
- Abramson RK, Wright HH, Carpenter R, Brennan W, Lumpuy O, Cole E, et al. Elevated blood serotonin in autistic probands and their first-degree relatives. J Autism Dev Disord. 1989;19:397–407. - PubMed
- Altamura C, Dell’Acqua ML, Moessner R, Murphy DL, Lesch KP, Persico AM. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: A quantitation study. Cereb Cortex. 2007;17:1394–1401. - PubMed
- Azmitia EC, Singh JS, Whitaker-Azmitia PM. Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. Neuropharmacology. 2011;60:1347–1354. - PubMed
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical