The molecular basis for neuroimmune receptor signaling
- PMID:22935971
- PMCID: PMC4011130
- DOI: 10.1007/s11481-012-9398-4
The molecular basis for neuroimmune receptor signaling
Abstract
Many of the receptors which are responsible for the responses to the common drugs of abuse belong to the G protein-coupled receptor (GPCR) family. In this special issue of the Journal of Neuroimmune Pharmacology a collection of papers is presented which deals with signaling events that are important for the function of these receptors. Because these receptors are expressed by both neuronal and immune cells, and because these receptors play a complex role in regulating function in both the nervous and immune systems, a more complete understanding of the regulation of expression of these receptors is essential. Moreover, once these receptors are expressed and activated, a complex series of signaling events are initiated that can have substantial significance. We have only a limited understanding of these signaling events, but with more complete information, we may be able to control the undesirable and/or desirable consequences of receptor activation by drugs of abuse.
Conflict of interest statement
Comment in
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Comment on
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- MicroRNAs in opioid pharmacology.Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH.Hwang CK, et al.J Neuroimmune Pharmacol. 2012 Dec;7(4):808-19. doi: 10.1007/s11481-011-9323-2. Epub 2011 Nov 9.J Neuroimmune Pharmacol. 2012.PMID:22068836Free PMC article.Review.
- Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain.Podhaizer EM, Zou S, Fitting S, Samano KL, El-Hage N, Knapp PE, Hauser KF.Podhaizer EM, et al.J Neuroimmune Pharmacol. 2012 Dec;7(4):877-91. doi: 10.1007/s11481-011-9326-z. Epub 2011 Nov 19.J Neuroimmune Pharmacol. 2012.PMID:22101471Free PMC article.
- CXCL12 signaling in the development of the nervous system.Mithal DS, Banisadr G, Miller RJ.Mithal DS, et al.J Neuroimmune Pharmacol. 2012 Dec;7(4):820-34. doi: 10.1007/s11481-011-9336-x. Epub 2012 Jan 21.J Neuroimmune Pharmacol. 2012.PMID:22270883Free PMC article.Review.
- The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55.Sharir H, Console-Bram L, Mundy C, Popoff SN, Kapur A, Abood ME.Sharir H, et al.J Neuroimmune Pharmacol. 2012 Dec;7(4):856-65. doi: 10.1007/s11481-012-9351-6. Epub 2012 Mar 28.J Neuroimmune Pharmacol. 2012.PMID:22454039Free PMC article.
- Regulation of mu opioid receptor expression in developing T cells.Zhang L, Belkowski JS, Briscoe T, Rogers TJ.Zhang L, et al.J Neuroimmune Pharmacol. 2012 Dec;7(4):835-42. doi: 10.1007/s11481-012-9396-6. Epub 2012 Aug 25.J Neuroimmune Pharmacol. 2012.PMID:22926418Free PMC article.
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