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Comment
.2012 Dec;7(4):722-4.
doi: 10.1007/s11481-012-9398-4. Epub 2012 Aug 31.

The molecular basis for neuroimmune receptor signaling

Comment

The molecular basis for neuroimmune receptor signaling

Thomas J Rogers. J Neuroimmune Pharmacol.2012 Dec.

Abstract

Many of the receptors which are responsible for the responses to the common drugs of abuse belong to the G protein-coupled receptor (GPCR) family. In this special issue of the Journal of Neuroimmune Pharmacology a collection of papers is presented which deals with signaling events that are important for the function of these receptors. Because these receptors are expressed by both neuronal and immune cells, and because these receptors play a complex role in regulating function in both the nervous and immune systems, a more complete understanding of the regulation of expression of these receptors is essential. Moreover, once these receptors are expressed and activated, a complex series of signaling events are initiated that can have substantial significance. We have only a limited understanding of these signaling events, but with more complete information, we may be able to control the undesirable and/or desirable consequences of receptor activation by drugs of abuse.

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Conflict of interest statement

Conflict of Interest Disclosure: The author has no known conflicts of interest concerning the results reported in this manuscript.

Comment in

  • Change in evolution.
    Gendelman HE.Gendelman HE.J Neuroimmune Pharmacol. 2012 Dec;7(4):715-6. doi: 10.1007/s11481-012-9418-4. Epub 2012 Nov 13.J Neuroimmune Pharmacol. 2012.PMID:23150033No abstract available.

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References

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