doi: 10.1126/science.2270484.
Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome
- PMID:2270484
- DOI: 10.1126/science.2270484
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Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome
A N Mayeno et al. Science..
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Abstract
Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan N alpha-animal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1'-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.
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