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.2012 Jul;65(7):355-9.
doi: 10.1038/ja.2012.30. Epub 2012 Apr 25.

Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura

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Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura

Yasuhiro Igarashi et al. J Antibiot (Tokyo).2012 Jul.

Abstract

Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture broth of an actinomycete of the genus Actinomadura. Its structure was established by spectroscopic methods, and the absolute configuration was determined by a combination of NOESY experiment, J-based configuration analysis and the modified Mosher method. Nomimicin (1) showed antimicrobial activity against Micrococcus luteus, Candida albicans and Kluyveromyces fragilis.

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