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.1990 Dec;10(12):6709-17.
doi: 10.1128/mcb.10.12.6709-6717.1990.

A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter

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A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter

L S Lum et al. Mol Cell Biol.1990 Dec.

Abstract

The basal promoter of the human hsp70 gene is predominantly controlled by a CCAAT element at position -70 relative to the transcriptional initiation site. We report the isolation of a novel cDNA clone encoding a 114-kDa polypeptide that binds to the CCAAT element of the hsp70 promoter. Expression of this CCAAT-binding factor (CBF) cDNA activated transcription from cotransfected hsp70 promoter-reporter gene constructs in a CCAAT-dependent manner. CCAAT-binding factor shows no homology to the previously identified human CCAAT transcription factor or rat CCAAT/enhancer-binding protein.

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References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
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