Review
doi: 10.1016/j.sbi.2012.01.007. Epub 2012 Feb 23.How SNARE molecules mediate membrane fusion: recent insights from molecular simulations
Affiliations
- PMID:22365575
- DOI: 10.1016/j.sbi.2012.01.007
Item in Clipboard
Review
How SNARE molecules mediate membrane fusion: recent insights from molecular simulations
Herre Jelger Risselada et al. Curr Opin Struct Biol.2012 Apr.
Display options
Format
Display options
Format
Abstract
SNARE molecules are the core constituents of the protein machinery that facilitate fusion of synaptic vesicles with the presynaptic plasma membrane, resulting in the release of neurotransmitter. On a molecular level, SNARE complexes seem to play a quite versatile and involved role during all stages of fusion. In addition to merely triggering fusion by forcing the opposing membranes into close proximity, SNARE complexes are now seen to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Here, we review recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
- Caught in the act: visualization of SNARE-mediated fusion events in molecular detail.Risselada HJ, Kutzner C, Grubmüller H.Risselada HJ, et al.Chembiochem. 2011 May 2;12(7):1049-55. doi: 10.1002/cbic.201100020. Epub 2011 Mar 23.Chembiochem. 2011.PMID:21433241
- Assembly and disassembly of SNAREs in membrane fusion.Jena BP.Jena BP.Methods Cell Biol. 2008;90:157-82. doi: 10.1016/S0091-679X(08)00808-X.Methods Cell Biol. 2008.PMID:19195550
- SNARE protein analog-mediated membrane fusion.Kumar P, Guha S, Diederichsen U.Kumar P, et al.J Pept Sci. 2015 Aug;21(8):621-9. doi: 10.1002/psc.2773. Epub 2015 Apr 7.J Pept Sci. 2015.PMID:25858776Review.
- Calcium drives fusion of SNARE-apposed bilayers.Jeremic A, Kelly M, Cho JA, Cho SJ, Horber JK, Jena BP.Jeremic A, et al.Cell Biol Int. 2004;28(1):19-31. doi: 10.1016/j.cellbi.2003.11.004.Cell Biol Int. 2004.PMID:14759765
- Role of SNAREs in membrane fusion.Jena BP.Jena BP.Adv Exp Med Biol. 2011;713:13-32. doi: 10.1007/978-94-007-0763-4_3.Adv Exp Med Biol. 2011.PMID:21432012Review.
Cited by
- Vacuolar SNARE protein transmembrane domains serve as nonspecific membrane anchors with unequal roles in lipid mixing.Pieren M, Desfougères Y, Michaillat L, Schmidt A, Mayer A.Pieren M, et al.J Biol Chem. 2015 May 15;290(20):12821-32. doi: 10.1074/jbc.M115.647776. Epub 2015 Mar 27.J Biol Chem. 2015.PMID:25817997Free PMC article.
- Super-resolution fluorescence imaging with single molecules.Sahl SJ, Moerner WE.Sahl SJ, et al.Curr Opin Struct Biol. 2013 Oct;23(5):778-87. doi: 10.1016/j.sbi.2013.07.010. Epub 2013 Aug 8.Curr Opin Struct Biol. 2013.PMID:23932284Free PMC article.Review.
- Influence of Membrane Phase on the Optical Properties of DPH.Osella S, Paloncýová M, Sahi M, Knippenberg S.Osella S, et al.Molecules. 2020 Sep 17;25(18):4264. doi: 10.3390/molecules25184264.Molecules. 2020.PMID:32957614Free PMC article.
- Simulations Reveal Multiple Intermediates in the Unzipping Mechanism of Neuronal SNARE Complex.Pinamonti G, Campo G, Chen J, Kluber A, Clementi C.Pinamonti G, et al.Biophys J. 2018 Oct 16;115(8):1470-1480. doi: 10.1016/j.bpj.2018.08.043. Epub 2018 Sep 7.Biophys J. 2018.PMID:30268539Free PMC article.
- SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis.Sharma P, Parveen S, Shah LV, Mukherjee M, Kalaidzidis Y, Kozielski AJ, Rosato R, Chang JC, Datta S.Sharma P, et al.J Cell Biol. 2020 Jan 6;219(1):e201812098. doi: 10.1083/jcb.201812098.J Cell Biol. 2020.PMID:31820782Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources