Randomized Controlled Trial
doi: 10.1001/archophthalmol.2011.2580.ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A
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- PMID:22332205
- PMCID: PMC3552384
- DOI: 10.1001/archophthalmol.2011.2580
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Randomized Controlled Trial
ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A
Eliot L Berson et al. Arch Ophthalmol.2012 Jun.
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Abstract
Objective: To evaluate whether a diet high in long chain ω-3 fatty acids can slow the rate of visual acuity loss among patients with retinitis pigmentosa receiving vitamin A palmitate.
Methods: We calculated dietary intake from questionnaires completed annually by 357 adult patients from 3 randomized trials who were all receiving vitamin A, 15 000 IU/d, for 4 to 6 years. Rates of visual acuity decline were compared between those with high (≥0.20 g/d) vs low (<0.20 g/d) ω-3 intake. Analyses took age into account.
Results: Mean rates of decline of acuity were slower among those with high ω-3 intake: Early Treatment Diabetic Retinopathy Study distance acuity: high intake=0.59 letter per year, low intake=1.00 letter per year,P=.001; Snellen retinal acuity: high intake=1.5% per year, low intake=2.8% per year, P=.03.
Conclusions: We conclude that mean annual rates of decline in distance and retinal visual acuities in adults with retinitis pigmentosa receiving vitamin A, 15 000 IU/d,are slower over 4 to 6 years among those consuming a diet rich in ω-3 fatty acids. To our knowledge, this is the first report that nutritional intake can modify the rate of decline of visual acuity in retinitis pigmentosa.
Figures
Mean log rates of decline of distance and retinal visual acuity for patients with high dietary omega-3 intake versus low dietary omega-3 intake. Data represent means and standard errors.
Mean log rates of decline of distance and retinal visual acuity for patients by quartile of dietary omega-3 intake in g/d: quartile 1: 0.002–0.138; quartile 2: 0.139–0.237; quartile 3: 0.237–0.382; quartile 4: 0.388–1.243. Data represent means and standard errors.
Comment in
- ω-3 Intake in patients with retinitis pigmentosa receiving vitamin A.Seigel D, Richoz O.Seigel D, et al.JAMA Ophthalmol. 2013 Feb;131(2):267-8. doi: 10.1001/jamaophthalmol.2013.590.JAMA Ophthalmol. 2013.PMID:23411905No abstract available.
- ω-3 Intake in patients with retinitis pigmentosa receiving vitamin A-Reply.Berson EL, Rosner B, Sandberg MA, Weigel-Difranco C, Willett WC.Berson EL, et al.JAMA Ophthalmol. 2013 Feb;131(2):267-8. doi: 10.1001/jamaophthalmol.2013.1722.JAMA Ophthalmol. 2013.PMID:23411906No abstract available.
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