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.2012 Jul;45(5):648-56.
doi: 10.1002/eat.20984. Epub 2012 Feb 13.

Striatal dopamine in bulimia nervosa: a PET imaging study

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Striatal dopamine in bulimia nervosa: a PET imaging study

Allegra Broft et al. Int J Eat Disord.2012 Jul.

Abstract

Objective: Bulimia nervosa (BN) has been characterized as similar to an addiction, though the empirical support for this characterization is limited. This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN.

Method: PET imaging with [(11) C]raclopride, pre/post methylphenidate administration, to assess dopamine type 2 (D(2)) receptor binding (BP(ND)) and striatal DA release (ΔBP(ND)).

Results: There was a trend toward lower D(2) receptor BP(ND) in two striatal subregions in the patient group when compared with the control group. DA release in the putamen in the patient group was significantly reduced and, overall, there was a trend toward a difference in striatal DA release. Striatal DA release was significantly associated with the frequency of binge eating.

Discussion: These data suggest that BN is characterized by abnormalities in brain DA that resemble, in some ways, those described in addictive disorders.

Copyright © 2012 Wiley Periodicals, Inc.

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Conflict of interest statement

The remaining authors (Broft, Shingleton, Kaufman, Liu, Kumar, Schebendach, Van Heertum, and Martinez) report no conflicts.

Figures

Figure 1
Figure 1. Scatterplots of between-group differences in dopamine (DA) type 2 (D2) receptor binding, and DA response to methylphenidate
A. Posterior putamen DA type 2 (D2) receptor binding potential (D2 BPnd; unitless), in control subjects (left) and patients with bulimia nervosa (right). B. A. Posterior caudate D2 receptor BPnd (D2 BPnd; unitless), in control subjects (left) and patients with bulimia nervosa (right). C. Striatal DA response (“DA release”), measured as the percent difference between the baseline PET scan and the post-methylphenidate scan, in control subjects (left) and patients with bulimia nervosa (right). D. Anterior putamen percent DA response in control subjects (left) and patients with bulimia nervosa (right). E. Anterior putamen percent DA response in control subjects (left) and patients with bulimia nervosa (right). For panels C-E, a more negative DA measure indicates greater DA response to methylphenidate.
See this image and copyright information in PMC

References

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