The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients
- PMID:21969075
- DOI: 10.1007/s10803-011-1373-z
The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients
Abstract
Autism and autism spectrum disorders (ASDs) are heterogeneous complex neuro-developmental disorders characterized by dysfunctions in social interaction and communication skills. Their pathogenesis has been linked to interactions between genes and environmental factors. Consistent with the evidence of certain similarities between immune cells and neurons, autistic children also show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the activation of caspases, cysteinyl aspartate-specific proteases involved in apoptosis and several other cell functions in PBMCs from 15 ASD children compared to age-matched normal healthy developing controls. The mRNA levels for caspase-1, -2, -4, -5 were significantly increased in ASD children as compared to healthy subjects. Protein levels of Caspase-3, -7, -12 were also increased in ASD patients. Our data are suggestive of a possible role of the caspase pathway in ASD clinical outcome and of the use of caspase as potential diagnostic and/or therapeutic tools in ASD management.
Similar articles
- Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.Siniscalco D, Sapone A, Giordano C, Cirillo A, de Magistris L, Rossi F, Fasano A, Bradstreet JJ, Maione S, Antonucci N.Siniscalco D, et al.J Autism Dev Disord. 2013 Nov;43(11):2686-95. doi: 10.1007/s10803-013-1824-9.J Autism Dev Disord. 2013.PMID:23585028
- Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study.Jyonouchi H, Geng L, Streck DL, Toruner GA.Jyonouchi H, et al.J Neuroinflammation. 2012 Jan 7;9:4. doi: 10.1186/1742-2094-9-4.J Neuroinflammation. 2012.PMID:22226452Free PMC article.
- Blood-based gene expression signatures of infants and toddlers with autism.Glatt SJ, Tsuang MT, Winn M, Chandler SD, Collins M, Lopez L, Weinfeld M, Carter C, Schork N, Pierce K, Courchesne E.Glatt SJ, et al.J Am Acad Child Adolesc Psychiatry. 2012 Sep;51(9):934-44.e2. doi: 10.1016/j.jaac.2012.07.007. Epub 2012 Aug 2.J Am Acad Child Adolesc Psychiatry. 2012.PMID:22917206Free PMC article.
- The genetics of autism.Muhle R, Trentacoste SV, Rapin I.Muhle R, et al.Pediatrics. 2004 May;113(5):e472-86. doi: 10.1542/peds.113.5.e472.Pediatrics. 2004.PMID:15121991Review.
- Association of Peripheral Blood Levels of Brain-Derived Neurotrophic Factor With Autism Spectrum Disorder in Children: A Systematic Review and Meta-analysis.Qin XY, Feng JC, Cao C, Wu HT, Loh YP, Cheng Y.Qin XY, et al.JAMA Pediatr. 2016 Nov 1;170(11):1079-1086. doi: 10.1001/jamapediatrics.2016.1626.JAMA Pediatr. 2016.PMID:27654278Review.
Cited by
- Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis.Asbjornsdottir B, Snorradottir H, Andresdottir E, Fasano A, Lauth B, Gudmundsson LS, Gottfredsson M, Halldorsson TI, Birgisdottir BE.Asbjornsdottir B, et al.Nutrients. 2020 Jul 3;12(7):1982. doi: 10.3390/nu12071982.Nutrients. 2020.PMID:32635367Free PMC article.
- Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder.Nakhal MM, Aburuz S, Sadek B, Akour A.Nakhal MM, et al.Molecules. 2022 Oct 23;27(21):7174. doi: 10.3390/molecules27217174.Molecules. 2022.PMID:36364000Free PMC article.Review.
- The searching for autism biomarkers: a commentary on: a new methodology of viewing extra-axial fluid and cortical abnormalities in children with autism via transcranial ultrasonography.Siniscalco D.Siniscalco D.Front Hum Neurosci. 2014 May 12;8:240. doi: 10.3389/fnhum.2014.00240. eCollection 2014.Front Hum Neurosci. 2014.PMID:24860465Free PMC article.No abstract available.
- Antibodies against food antigens in patients with autistic spectrum disorders.de Magistris L, Picardi A, Siniscalco D, Riccio MP, Sapone A, Cariello R, Abbadessa S, Medici N, Lammers KM, Schiraldi C, Iardino P, Marotta R, Tolone C, Fasano A, Pascotto A, Bravaccio C.de Magistris L, et al.Biomed Res Int. 2013;2013:729349. doi: 10.1155/2013/729349. Epub 2013 Aug 1.Biomed Res Int. 2013.PMID:23984403Free PMC article.
- Commentary: The Impact of Neuroimmune Alterations in Autism Spectrum Disorder.Siniscalco D.Siniscalco D.Front Psychiatry. 2015 Oct 8;6:145. doi: 10.3389/fpsyt.2015.00145. eCollection 2015.Front Psychiatry. 2015.PMID:26500565Free PMC article.No abstract available.
References
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Research Materials