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.2011 Oct 7;334(6052):94-8.
doi: 10.1126/science.1211177. Epub 2011 Sep 22.

An Aboriginal Australian genome reveals separate human dispersals into Asia

Morten Rasmussen  1, Xiaosen Guo, Yong Wang, Kirk E Lohmueller, Simon Rasmussen, Anders Albrechtsen, Line Skotte, Stinus Lindgreen, Mait Metspalu, Thibaut Jombart, Toomas Kivisild, Weiwei Zhai, Anders Eriksson, Andrea Manica, Ludovic Orlando, Francisco M De La Vega, Silvana Tridico, Ene Metspalu, Kasper Nielsen, María C Ávila-Arcos, J Víctor Moreno-Mayar, Craig Muller, Joe Dortch, M Thomas P Gilbert, Ole Lund, Agata Wesolowska, Monika Karmin, Lucy A Weinert, Bo Wang, Jun Li, Shuaishuai Tai, Fei Xiao, Tsunehiko Hanihara, George van Driem, Aashish R Jha, François-Xavier Ricaut, Peter de Knijff, Andrea B Migliano, Irene Gallego Romero, Karsten Kristiansen, David M Lambert, Søren Brunak, Peter Forster, Bernd Brinkmann, Olaf Nehlich, Michael Bunce, Michael Richards, Ramneek Gupta, Carlos D Bustamante, Anders Krogh, Robert A Foley, Marta M Lahr, Francois Balloux, Thomas Sicheritz-Pontén, Richard Villems, Rasmus Nielsen, Jun Wang, Eske Willerslev
Affiliations

An Aboriginal Australian genome reveals separate human dispersals into Asia

Morten Rasmussen et al. Science..

Abstract

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

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Figures

Fig 1
Fig 1
(A) The two models for early dispersal of modern humans into eastern Asia. Top: Single-dispersal model predicting a single early dispersal of modern humans into eastern Asia. Bottom: Multiple-dispersal model predicting separate dispersals into eastern Asia of aboriginal Australasians and the ancestors of most other present-day East Asians. AF, Africans; EU, Europeans; ASN, Asians; ABR, Aboriginal Australians. Arrow symbolizes gene flow. (B) PCA plot (PC1 versus PC2) of the studied populations and the ancient genome of the Aboriginal Australian (marked with a cross). Inset shows the greater Australia populations (4). (C) Ancestry proportions of the studied 1220 individuals from 79 populations and the ancient Aboriginal Australian as revealed by the ADMIXTURE program (28) withK = 5,K = 11, andK = 20. A stacked column of theK proportions represents each individual, with fractions indicated on they axis [see (4) for the choice ofK]. The greater Australia populations are shown in detail at the upper right.
Fig 2
Fig 2
Reconstruction of early spread of modern humans outside Africa. The tree shows the divergence of the Aboriginal Australian (ABR) relative to the CEPH European (CEU) and the Han Chinese (HAN) with gene flow between aboriginal Australasians and Asian ancestors. Purple arrow shows early spread of the ancestors of Aboriginal Australians into eastern Asia ~62,000 to 75,000 years B.P. (ka BP), exchanging genes with Denisovans, and reaching Australia ~50,000 years B.P. Black arrow shows spread of East Asians ~25,000 to 38,000 years B.P. and admixing with remnants of the early dispersal (red arrow) some time before the split between Asians and Native American ancestors ~15,000 to 30,000 years B.P. YRI, Yoruba.
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References

    1. Ramachandran S, et al. Proc. Natl. Acad. Sci. U.S.A. 2005;102:15942. - PMC - PubMed
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    1. HUGO Pan-Asian SNP Consortium. Science. 2009;326:1541. - PubMed

    1. See supporting material onScience Online.

    1. Gutenkunst RN, Hernandez RD, Williamson SH, Bustamante CD. PLoS Genet. 2009;5:e1000695. - PMC - PubMed

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