Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
- PMID:21722657
- DOI: 10.1016/j.physbeh.2011.06.005
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
Abstract
Physical activity has been reported to improve cognitive function in humans and rodents, possibly via a brain-derived neurotrophic factor (BDNF)-regulated mechanism. In this study of human subjects, we have assessed the effects of acute and chronic exercise on performance of a face-name matching task, which recruits the hippocampus and associated structures of the medial temporal lobe, and the Stroop word-colour task, which does not, and have assessed circulating concentrations of BDNF and IGF-1 in parallel. The results show that a short period of high-intensity cycling results in enhancements in performance of the face-name matching, but not the Stroop, task. These changes in cognitive function were paralleled by increased concentration of BDNF, but not IGF-1, in the serum of exercising subjects. 3 weeks of cycling training had no effect on cardiovascular fitness, as assessed by VO2 scores, cognitive function, or serum BDNF concentration. Increases in fitness, cognitive function and serum BDNF response to acute exercise were observed following 5 weeks of aerobic training. These data indicate that both acute and chronic exercise improve medial temporal lobe function concomitant with increased concentrations of BDNF in the serum, suggesting a possible functional role for this neurotrophic factor in exercise-induced cognitive enhancement in humans.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
- Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism.Griffin EW, Bechara RG, Birch AM, Kelly AM.Griffin EW, et al.Hippocampus. 2009 Oct;19(10):973-80. doi: 10.1002/hipo.20631.Hippocampus. 2009.PMID:19437410
- Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor?Goekint M, Roelands B, De Pauw K, Knaepen K, Bos I, Meeusen R.Goekint M, et al.Neurosci Lett. 2010 Dec 17;486(3):146-9. doi: 10.1016/j.neulet.2010.09.032. Epub 2010 Sep 17.Neurosci Lett. 2010.PMID:20854879
- The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function.Ferris LT, Williams JS, Shen CL.Ferris LT, et al.Med Sci Sports Exerc. 2007 Apr;39(4):728-34. doi: 10.1249/mss.0b013e31802f04c7.Med Sci Sports Exerc. 2007.PMID:17414812
- Effect of resistance exercise on serum levels of growth factors in humans.Rojas Vega S, Knicker A, Hollmann W, Bloch W, Strüder HK.Rojas Vega S, et al.Horm Metab Res. 2010 Dec;42(13):982-6. doi: 10.1055/s-0030-1267950. Epub 2010 Nov 4.Horm Metab Res. 2010.PMID:21053157Review.
- The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies.Zoladz JA, Pilc A.Zoladz JA, et al.J Physiol Pharmacol. 2010 Oct;61(5):533-41.J Physiol Pharmacol. 2010.PMID:21081796Review.
Cited by
- Acute effects of two different work-to-rest ratio of high-intensity interval training on brain-derived neurotrophic factor in untrained young men.Zhao K, Hu Z, Wang T, Tian L, Wang M, Liu R, Zuo C, Jihua W.Zhao K, et al.Front Physiol. 2022 Sep 7;13:988773. doi: 10.3389/fphys.2022.988773. eCollection 2022.Front Physiol. 2022.PMID:36160866Free PMC article.
- High Intensity Acute Aerobic Exercise Elicits Alterations in Circulating and Skeletal Muscle Tissue Expression of Neuroprotective Exerkines.Mazo CE, Miranda ER, Shadiow J, Vesia M, Haus JM.Mazo CE, et al.Brain Plast. 2022 Oct 21;8(1):5-18. doi: 10.3233/BPL-220137. eCollection 2022.Brain Plast. 2022.PMID:36448040Free PMC article.
- Polyphenols: Secondary Metabolites with a Biological Impression.Bolat E, Sarıtaş S, Duman H, Eker F, Akdaşçi E, Karav S, Witkowska AM.Bolat E, et al.Nutrients. 2024 Aug 3;16(15):2550. doi: 10.3390/nu16152550.Nutrients. 2024.PMID:39125431Free PMC article.Review.
- The effectiveness of heat preparation and alleviation strategies for cognitive performance: A systematic review.Donnan KJ, Williams EL, Bargh MJ.Donnan KJ, et al.Temperature (Austin). 2023 Jan 4;10(4):404-433. doi: 10.1080/23328940.2022.2157645. eCollection 2023.Temperature (Austin). 2023.PMID:38130656Free PMC article.Review.
- Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials.Shobeiri P, Karimi A, Momtazmanesh S, Teixeira AL, Teunissen CE, van Wegen EEH, Hirsch MA, Yekaninejad MS, Rezaei N.Shobeiri P, et al.PLoS One. 2022 Mar 3;17(3):e0264557. doi: 10.1371/journal.pone.0264557. eCollection 2022.PLoS One. 2022.PMID:35239684Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous