doi: 10.1038/nchem.544. Epub 2010 Feb 7.
Synthesis of a molecular trefoil knot by folding and closing on an octahedral coordination template
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- PMID:21124480
- DOI: 10.1038/nchem.544
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Synthesis of a molecular trefoil knot by folding and closing on an octahedral coordination template
Jun Guo et al. Nat Chem.2010 Mar.
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Abstract
The advent of template-directed synthesis has provided access to a range of new interlocked molecular architectures. Although many syntheses of molecular catenanes and rotaxanes have been reported, molecular knots are a class of molecules with topologically non-planar graphs that are rather rare. Here we report a synthetic strategy for the preparation of a molecular trefoil knot from a flexible bipyridine oligomer and a zinc(II) octahedral coordination template. The oligomer folds into a stable open-knot conformation in the presence of the template, and trapping of this arrangement through esterification or ring-closing metathesis produces the closed-knot complex. Subsequent removal of the template from the metathesis product results in a molecular trefoil knot.
Comment in
- Chemical topology: tying up some loose ends.Fenlon EE.Fenlon EE.Nat Chem. 2010 Mar;2(3):156-7. doi: 10.1038/nchem.561. Epub 2010 Feb 7.Nat Chem. 2010.PMID:21124466No abstract available.
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