5-HTTLPR polymorphism in the serotonin transporter gene and migraine: a systematic review and meta-analysis
- PMID:20959425
- PMCID: PMC3055240
- DOI: 10.1177/0333102410362929
5-HTTLPR polymorphism in the serotonin transporter gene and migraine: a systematic review and meta-analysis
Abstract
Background and methods: Data on the association between the SLC6A4 5-HTTLPR polymorphism and migraine are conflicting. We performed a systematic review and meta-analysis among studies published up to September 2009. For each study with genotype information, we calculated odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.
Results: Among the ten studies identified there was no overall association between the polymorphism and any migraine for Europeans or Asians. However, European women carrying the S allele had an increased risk for any migraine (dominant model: pooled OR=2.02; 95% CI 1.24-3.28). Results among Europeans further suggested an increased risk for migraine with aura among carriers of the S/S genotype (recessive model: pooled OR=1.41; 95% CI 0.83-2.40).
Conclusions: While our results indicate no overall association between the SLC6A4 5-HTTLPR polymorphism and migraine among Europeans and Asians, gender and migraine aura status may have modifying roles among Europeans.
Similar articles
- STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses.Schürks M, Rist PM, Kurth T.Schürks M, et al.J Headache Pain. 2010 Aug;11(4):317-26. doi: 10.1007/s10194-010-0230-3. Epub 2010 Jun 29.J Headache Pain. 2010.PMID:20585826Free PMC article.Review.
- A serotonin transporter gene (SLC6A4) polymorphism is associated with reduced risk of irritable bowel syndrome in American and Asian population: a meta-analysis.Areeshi MY, Haque S, Panda AK, Mandal RK.Areeshi MY, et al.PLoS One. 2013 Sep 19;8(9):e75567. doi: 10.1371/journal.pone.0075567. eCollection 2013.PLoS One. 2013.PMID:24069428Free PMC article.
- MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.Schürks M, Rist PM, Kurth T.Schürks M, et al.Headache. 2010 Apr;50(4):588-99. doi: 10.1111/j.1526-4610.2009.01570.x. Epub 2009 Nov 17.Headache. 2010.PMID:19925624Free PMC article.Review.
- Serotonin transporter gene polymorphism and migraine in the Korean population.Kim WK, Kim HS, Kim WJ, Lee KY, Park H, Kim CH, Kim SJ, Choi YC.Kim WK, et al.Headache. 2005 Sep;45(8):1056-60. doi: 10.1111/j.1526-4610.2005.05187.x.Headache. 2005.PMID:16109120
- No influence of 5-HTTLPR gene polymorphism on migraine symptomatology, comorbid depression, and chronification.Wieser T, Dresler K, Evers S, Gaul C, König D, Hölzl D, Berger K, Nyholt D, Deufel T.Wieser T, et al.Headache. 2010 Mar;50(3):420-30. doi: 10.1111/j.1526-4610.2009.01428.x. Epub 2009 Apr 27.Headache. 2010.PMID:19438736
Cited by
- STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses.Schürks M, Rist PM, Kurth T.Schürks M, et al.J Headache Pain. 2010 Aug;11(4):317-26. doi: 10.1007/s10194-010-0230-3. Epub 2010 Jun 29.J Headache Pain. 2010.PMID:20585826Free PMC article.Review.
- Genetics of migraine in the age of genome-wide association studies.Schürks M.Schürks M.J Headache Pain. 2012 Jan;13(1):1-9. doi: 10.1007/s10194-011-0399-0. Epub 2011 Nov 11.J Headache Pain. 2012.PMID:22072275Free PMC article.Review.
- Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache.Schürks M, Frahnow A, Diener HC, Kurth T, Rosskopf D, Grabe HJ.Schürks M, et al.J Headache Pain. 2014 Jul 21;15(1):46. doi: 10.1186/1129-2377-15-46.J Headache Pain. 2014.PMID:25043824Free PMC article.
- Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.Jacobsen KK, Nievergelt CM, Zayats T, Greenwood TA, Anttila V, Akiskal HS; BiGS Consortium; IHG Consortium; Haavik J, Bernt Fasmer O, Kelsoe JR, Johansson S, Oedegaard KJ.Jacobsen KK, et al.J Affect Disord. 2015 Feb 1;172:453-61. doi: 10.1016/j.jad.2014.10.004. Epub 2014 Oct 12.J Affect Disord. 2015.PMID:25451450Free PMC article.
- Pharmacogenetics of chronic pain and its treatment.Světlík S, Hronová K, Bakhouche H, Matoušková O, Slanař O.Světlík S, et al.Mediators Inflamm. 2013;2013:864319. doi: 10.1155/2013/864319. Epub 2013 May 20.Mediators Inflamm. 2013.PMID:23766564Free PMC article.Review.
References
- Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci. 2003;4:386–98. - PubMed
- Hamel E. Serotonin and migraine: biology and clinical implications. Cephalalgia. 2007;27:1293–300. - PubMed
- Rudnick G, Clark J. From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochimica et Biophysica Acta. 1993;1144:249–63. - PubMed
- Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proceedings of the National Academy of Sciences of the United States of America. 1993;90:2542–6. - PMC - PubMed
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous