Combination HIV prevention: significance, challenges, and opportunities
- PMID:20941553
- PMCID: PMC3036787
- DOI: 10.1007/s11904-010-0063-3
Combination HIV prevention: significance, challenges, and opportunities
Abstract
No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop "prevention packages" that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.
Conflict of interest statement
Similar articles
- Control of sexually transmitted infections and prevention of HIV transmission: mending a fractured paradigm.Steen R, Wi TE, Kamali A, Ndowa F.Steen R, et al.Bull World Health Organ. 2009 Nov;87(11):858-65. doi: 10.2471/blt.08.059212.Bull World Health Organ. 2009.PMID:20072772Free PMC article.
- Sexual and reproductive health in HIV-related proposals supported by the Global Fund to Fight AIDS, Tuberculosis and Malaria.Lusti-Narasimhan M, Collin C, Mbizvo M.Lusti-Narasimhan M, et al.Bull World Health Organ. 2009 Nov;87(11):816-23. doi: 10.2471/blt.08.059147.Bull World Health Organ. 2009.PMID:20072766Free PMC article.
- Behavioral and biomedical combination strategies for HIV prevention.Bekker LG, Beyrer C, Quinn TC.Bekker LG, et al.Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a007435. doi: 10.1101/cshperspect.a007435.Cold Spring Harb Perspect Med. 2012.PMID:22908192Free PMC article.Review.
- Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men.Johnson WD, Diaz RM, Flanders WD, Goodman M, Hill AN, Holtgrave D, Malow R, McClellan WM.Johnson WD, et al.Cochrane Database Syst Rev. 2008 Jul 16;(3):CD001230. doi: 10.1002/14651858.CD001230.pub2.Cochrane Database Syst Rev. 2008.PMID:18646068Review.
- Population-based interventions for reducing sexually transmitted infections, including HIV infection.Sangani P, Rutherford G, Wilkinson D.Sangani P, et al.Cochrane Database Syst Rev. 2004;(2):CD001220. doi: 10.1002/14651858.CD001220.pub2.Cochrane Database Syst Rev. 2004.Update in:Cochrane Database Syst Rev. 2011 Mar 16;(3):CD001220. doi: 10.1002/14651858.CD001220.pub3.PMID:15106156Updated.Review.
Cited by
- What do patients consulting in a free sexual health center know about HIV transmission and post-exposure prophylaxis?Duteil C, de La Rochebrochard E, Piron P, Segouin C, Troude P.Duteil C, et al.BMC Public Health. 2021 Mar 12;21(1):494. doi: 10.1186/s12889-021-10547-9.BMC Public Health. 2021.PMID:33711979Free PMC article.
- Different guidelines for pre-exposure prophylaxis (PrEP) eligibility estimate HIV risk differently: an incidence study in a cohort of HIV-negative men who have sex with men, Portugal, 2014-2018.Meireles P, Plankey M, Rocha M, Brito J, Mendão L, Barros H.Meireles P, et al.Euro Surveill. 2020 Jul;25(28):1900636. doi: 10.2807/1560-7917.ES.2020.25.28.1900636.Euro Surveill. 2020.PMID:32700673Free PMC article.
- Towards combination HIV prevention for injection drug users: addressing addictophobia, apathy and inattention.Strathdee SA, Shoptaw S, Dyer TP, Quan VM, Aramrattana A; Substance Use Scientific Committee of the HIV Prevention Trials Network.Strathdee SA, et al.Curr Opin HIV AIDS. 2012 Jul;7(4):320-5. doi: 10.1097/COH.0b013e32835369ad.Curr Opin HIV AIDS. 2012.PMID:22498479Free PMC article.Review.
- Effects of combination approach on harm reduction programs: the Taiwan experience.Lin T, Chen CH, Chou P.Lin T, et al.Harm Reduct J. 2016 Jul 4;13(1):23. doi: 10.1186/s12954-016-0112-3.Harm Reduct J. 2016.PMID:27377896Free PMC article.
- Strategies for increasing impact, engagement, and accessibility in HIV prevention programs: suggestions from women in urban high HIV burden counties in the Eastern United States (HPTN 064).Abrams JA, Odlum M, Tillett E, Haley D, Justman J, Hodder S, Vo L, O'Leary A, Frew PM; HIV Prevention Trials Network 064 (HTPN) Study Team.Abrams JA, et al.BMC Public Health. 2020 Sep 3;20(1):1340. doi: 10.1186/s12889-020-09426-6.BMC Public Health. 2020.PMID:32883248Free PMC article.
References
- Geneva, Switzerland: UNAIDS; 2009. WHO, UNAIDS: AIDS epidemic update: December 2009.
- Vermund SH. Rationale for the testing and use of a partially effective HIV vaccine. AIDS Res Hum Retroviruses. 1998;14 Suppl 3:S321–S323. - PubMed
- Vergidis PI, Falagas ME. Meta-analyses on behavioral interventions to reduce the risk of transmission of HIV. Infect Dis Clin North Am. 2009;23:309–314. - PubMed
- Johnson WD, et al. Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database Syst Rev. 2008:CD001230. - PubMed
- Herbst JH, et al. A meta-analytic review of HIV behavioral interventions for reducing sexual risk behavior of men who have sex with men. J Acquir Immune Defic Syndr. 2005;39:228–241. - PubMed
Publication types
MeSH terms
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Medical