Research and development of antischistosomal drugs in the People's Republic of China a 60-year review
- PMID:20627145
- DOI: 10.1016/S0065-308X(10)73009-8
Research and development of antischistosomal drugs in the People's Republic of China a 60-year review
Abstract
A comprehensive 60-year review of antischistosomal drug discovery and development research in the People's Republic of China (P.R. China) is presented. In the 1950s, three antimonials were developed, which, compared to potassium antimony tartrate-the treatment of choice against schistosomiasis at the time-showed equal efficacy but lower toxicity when administered orally or intramuscularly. Activity of furapromidum against Schistosoma japonicum was reported in the early 1960s, and this drug became the first non-antimonial used in clinical treatment of schistosomiasis japonica. Subsequently, two additional nitrofuran derivatives (furadiamine and fuvinazole) were investigated in the laboratory and clinically. In the late 1960s, niridazole and amoscanate were developed by western scientists, which encouraged Chinese researchers to synthesise and further modify the chemical structures of these compounds. However, the modified compounds were less efficacious but similarly toxic, which impeded their further development. The advent of the safe, highly efficacious broad-spectrum antischistosomal drug praziquantel, in the mid-1970s, eventually resulted in a change of the global schistosomiasis control strategy from a multi-pronged transmission control approach to drug-based morbidity control. Numerous studies were carried out in P.R. China to further the understanding of efficacy, mechanism of action and safety of praziquantel against S. japonicum. Efforts have also been made to develop antischistosomal drugs from Chinese traditional medicine, and research with cucurbitin (an amino acid isolated from pumpkin seeds), among other products, showed interesting in vitro and in vivo activities against S. japonicum. In the 1990s, the artemisinins-originally reserved for malaria treatment-were developed as 'chemoprophylactic' agents against S. japonicum, which in turn led to a series of new developments of artemisinins and related compounds as broad-spectrum antischistosomal and anthelminthic therapies.
Copyright 2010 Elsevier Ltd. All rights reserved.
Similar articles
- Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins.Xiao SH.Xiao SH.Acta Trop. 2005 Nov-Dec;96(2-3):153-67. doi: 10.1016/j.actatropica.2005.07.010. Epub 2005 Aug 19.Acta Trop. 2005.PMID:16112072Review.
- Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China.Wang W, Dai JR, Li HJ, Shen XH, Liang YS.Wang W, et al.Parasitology. 2010 Nov;137(13):1905-12. doi: 10.1017/S0031182010001204.Parasitology. 2010.PMID:20810006
- [Studies on resistance of Schistosoma to praziquantel XIII resistance of Schistosoma japonicum to praziquantel is experimentally induced in laboratory].Liang YS, Li HJ, Dai JR, Wang W, Qu GL, Tao YH, Xing YT, Li YZ, Qian K, Wei JY.Liang YS, et al.Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011 Dec;23(6):605-10.Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011.PMID:22379812Chinese.
- Design, synthesis and biological evaluation of praziquantel and endoperoxide conjugates as antischistosomal agents.Yang JJ, Boissier J, Chen JL, Yao H, Yang S, Rognon A, Qiao C.Yang JJ, et al.Future Med Chem. 2015;7(6):713-25. doi: 10.4155/fmc.15.20.Future Med Chem. 2015.PMID:25996065
- Towards the Elimination of Schistosomiasis japonica through Control of the Disease in Domestic Animals in The People's Republic of China: A Tale of over 60Years.Cao ZG, Zhao YE, Lee Willingham A, Wang TP.Cao ZG, et al.Adv Parasitol. 2016;92:269-306. doi: 10.1016/bs.apar.2016.03.001. Epub 2016 Apr 7.Adv Parasitol. 2016.PMID:27137450Review.
Cited by
- Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice.Huang YX, Xu YL, Yu CX, Li HJ, Yin XR, Wang TS, Wang W, Liang YS.Huang YX, et al.Parasitol Res. 2011 Nov;109(5):1453-9. doi: 10.1007/s00436-011-2485-2. Epub 2011 Jun 22.Parasitol Res. 2011.PMID:21695570
- Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?Bergquist R, Utzinger J, Keiser J.Bergquist R, et al.Infect Dis Poverty. 2017 Mar 28;6(1):74. doi: 10.1186/s40249-017-0286-2.Infect Dis Poverty. 2017.PMID:28351414Free PMC article.Review.
- Susceptibility or resistance of praziquantel in human schistosomiasis: a review.Wang W, Wang L, Liang YS.Wang W, et al.Parasitol Res. 2012 Nov;111(5):1871-7. doi: 10.1007/s00436-012-3151-z. Epub 2012 Oct 7.Parasitol Res. 2012.PMID:23052781Review.
- Anthelmintic potential of sulphonamides andCucurbita pepo seeds extract onHeterophyes heterophyes experimentally infected mice.Ashour DS, Deyab FA, Eliwa KF, El-Kowrany SI.Ashour DS, et al.J Parasit Dis. 2023 Dec;47(4):697-706. doi: 10.1007/s12639-023-01620-8. Epub 2023 Jul 26.J Parasit Dis. 2023.PMID:38009148Free PMC article.
- Water-related parasitic diseases in China.Lv S, Tian LG, Liu Q, Qian MB, Fu Q, Steinmann P, Chen JX, Yang GJ, Yang K, Zhou XN.Lv S, et al.Int J Environ Res Public Health. 2013 May 17;10(5):1977-2016. doi: 10.3390/ijerph10051977.Int J Environ Res Public Health. 2013.PMID:23685826Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources