Review
doi: 10.1038/nri2800. Epub 2010 Jun 18.Innate IL-17-producing cells: the sentinels of the immune system
Affiliations
- PMID:20559326
- DOI: 10.1038/nri2800
Item in Clipboard
Review
Innate IL-17-producing cells: the sentinels of the immune system
Daniel J Cua et al. Nat Rev Immunol.2010 Jul.
Display options
Format
Display options
Format
Erratum in
- Nat Rev Immunol. 2010 Aug;10(8):611
- Nat Rev Immunol. 2010 Jul;10(7):following 489
Abstract
The cytokine interleukin-17 (IL-17) has received considerable attention since the discovery of a distinct CD4(+) T helper (T(H)) cell subset that produces it, known as the T(H)17 cell subset. Despite the fact that most of the recent literature describes IL-17 as a T cell-secreted cytokine, much of the IL-17 released during an inflammatory response is produced by innate immune cells. In this Review, we explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antigen and initiates the T(H)17 cell developmental programme.
Similar articles
- Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals.Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M.Martin B, et al.Immunity. 2009 Aug 21;31(2):321-30. doi: 10.1016/j.immuni.2009.06.020. Epub 2009 Aug 13.Immunity. 2009.PMID:19682928
- Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH.Sutton CE, et al.Immunity. 2009 Aug 21;31(2):331-41. doi: 10.1016/j.immuni.2009.08.001. Epub 2009 Aug 13.Immunity. 2009.PMID:19682929
- Gammadelta T cell receptors without a job.Kapsenberg ML.Kapsenberg ML.Immunity. 2009 Aug 21;31(2):181-3. doi: 10.1016/j.immuni.2009.08.004.Immunity. 2009.PMID:19699169
- T helper 17 cells: discovery, function, and physiological trigger.Torchinsky MB, Blander JM.Torchinsky MB, et al.Cell Mol Life Sci. 2010 May;67(9):1407-21. doi: 10.1007/s00018-009-0248-3. Epub 2010 Jan 7.Cell Mol Life Sci. 2010.PMID:20054607Free PMC article.Review.
- Th17 T cells: linking innate and adaptive immunity.Stockinger B, Veldhoen M, Martin B.Stockinger B, et al.Semin Immunol. 2007 Dec;19(6):353-61. doi: 10.1016/j.smim.2007.10.008. Epub 2007 Nov 26.Semin Immunol. 2007.PMID:18023589Review.
Cited by
- T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells.Wang W, Sung N, Gilman-Sachs A, Kwak-Kim J.Wang W, et al.Front Immunol. 2020 Aug 18;11:2025. doi: 10.3389/fimmu.2020.02025. eCollection 2020.Front Immunol. 2020.PMID:32973809Free PMC article.Review.
- IL-17 induces expression of vascular cell adhesion molecule through signalling pathway of NF-κB, but not Akt1 and TAK1 in vascular smooth muscle cells.Zhang H, Chen J, Liu X, Awar L, McMickle A, Bai F, Nagarajan S, Yu S.Zhang H, et al.Scand J Immunol. 2013 Apr;77(4):230-7. doi: 10.1111/sji.12030.Scand J Immunol. 2013.PMID:23421430Free PMC article.
- Luobitong Potentiates MTX's Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways.Li Z, Zhang Q, Gao Y, Wan F, Wang Y, Hou B, Cui W, Wang Y, Feng W, Hou Y.Li Z, et al.J Inflamm Res. 2024 Jul 6;17:4389-4403. doi: 10.2147/JIR.S461093. eCollection 2024.J Inflamm Res. 2024.PMID:38994468Free PMC article.
- IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.Lee KT, Lin CY, Liu SC, He XY, Tsai CH, Ko CY, Tsai YH, Chao CC, Chen PC, Tang CH.Lee KT, et al.Aging (Albany NY). 2024 Jan 22;16(2):1829-1844. doi: 10.18632/aging.205462. Epub 2024 Jan 22.Aging (Albany NY). 2024.PMID:38261743Free PMC article.
- Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies.Yasmeen F, Pirzada RH, Ahmad B, Choi B, Choi S.Yasmeen F, et al.Int J Mol Sci. 2024 Jul 12;25(14):7666. doi: 10.3390/ijms25147666.Int J Mol Sci. 2024.PMID:39062908Free PMC article.Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials