Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Springer full text link Springer Free PMC article
Full text links

Actions

Share

Comparative Study
.2010 Oct;33(5):355-63.
doi: 10.1007/s10865-010-9266-8. Epub 2010 May 28.

Fatigue and physical disability in patients with multiple sclerosis: a structural equation modeling approach

Affiliations
Comparative Study

Fatigue and physical disability in patients with multiple sclerosis: a structural equation modeling approach

Yvonne Bol et al. J Behav Med.2010 Oct.

Abstract

Although fatigue is one of the most common and disabling symptoms in patients with multiple sclerosis (MS), its pathogenesis is still poorly understood and it is difficult to treat. The aim of the current study was to test the assumptions of a cognitive-behavioral model that explains fatigue and physical disability in MS patients, by comparing this approach with a more traditional biomedical approach. Structural equation modeling was applied to a sample of 262 MS patients. Neither the cognitive-behavioral, nor the biomedical model showed an adequate fit of our data. The modification indices supported an integration of both models, which showed a better fit than those of the separate models. This final model, is notable for at least three features: (1) fatigue is associated with depression and physical disability, (2) physical disability is associated with disease severity and fatigue-related fear and avoidance behavior, and (3) catastrophic interpretations about fatigue, fueled by depression, mediated the relationship between fatigue and fatigue-related fear and avoidance behavior. Our results suggest that an integrated approach, including the modification of catastrophic thoughts about fatigue, would be beneficial in the treatment of fatigue in MS patients.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Cognitive-behavioral model.Fear-Avoidance Fatigue-related fear and avoidance behavior,Catastrophizing catastrophizing about fatigue. Values shown are standardized regression coefficients. Explained variances are provided in parentheses. * p < .01; ** p < .0.001
Fig. 2
Fig. 2
Biomedical model.Fear-Avoidance Fatigue-related fear and avoidance behavior,Catastrophizing catastrophizing about fatigue. Values shown are standardized regression coefficients. Explained variances are provided in parentheses. * p < .01; ** p < .0.001
Fig. 3
Fig. 3
Final model.Fear-Avoidance Fatigue-related fear and avoidance behavior,catastrophizing catastrophizing about fatigue. Values shown are standardized regression coefficients. Explained variances are provided in parentheses. * p < .01; ** p < .0.001
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Aaronson NK, Muller M, Cohen PD, Essink-Bot ML, Fekkes M, Sanderman R, et al. Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations. Journal of Clinical Epidemiology. 1998;51(11):1055–1068. doi: 10.1016/S0895-4356(98)00097-3. - DOI - PubMed
    1. Alberts M, Smets EM, Vercoulen JH, Garssen B, Bleijenberg G. ‘Abbreviated fatigue questionnaire’: A practical tool in the classification of fatigue. Nederlands Tijdschrift voor Geneeskunde. 1997;141(31):1526–1530. - PubMed
    1. Amato MP, Ponziani G, Rossi F, Liedl CL, Stefanile C, Rossi L. Quality of life in multiple sclerosis: The impact of depression, fatigue and disability. Multiple Sclerosis. 2001;7(5):340–344. - PubMed
    1. Andrea H, Beurskens AJ, Kant I, Davey GC, Field AP, van Schayck CP. The relation between pathological worrying and fatigue in a working population. Journal of Psychosomatic Research. 2004;57(4):399–407. - PubMed
    1. Arbuckle JL. Amos 16.0 user’s guide. Spring House: Amos Development Corporation; 2007.

Publication types

MeSH terms

Related information

LinkOut - more resources

Full text links
Springer full text link Springer Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp