doi: 10.1126/science.2017683.
Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release
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- PMID:2017683
- DOI: 10.1126/science.2017683
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Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release
E A Finch et al. Science..
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Abstract
Inositol 1,4,5-trisphosphate (IP3)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP3-induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP3-induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP3-induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP3-induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP3-induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.
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