Hormonal therapy for acne: why not as first line therapy? facts and controversies
- PMID:20082945
- DOI: 10.1016/j.clindermatol.2009.03.006
Hormonal therapy for acne: why not as first line therapy? facts and controversies
Abstract
Standard systemic therapeutic agents used in acne include oral antimicrobials, isotretinoin, and hormonal agents. Appropriate patient selection is the key to decide when to use hormonal agents as first-line therapy as well as to achieve optimal results. Indications of hormonal therapy in acne in girls and women include proven ovarian or adrenal hyperandrogenism, recalcitrant acne, acne not responding to repeated courses of oral isotretinoin, acne tarda, polycystic ovary syndrome, or the presence of clinical signs of hyperandrogenism such as androgenic alopecia or the presence of the seborrhea, acne, hirsutism, alopecia syndrome. We describe the hormonal agents currently available for acne treatment, discuss their indications and contraindications, and address the question of whether they may be used as a first-line therapy in acne.
Copyright 2010 Elsevier Inc. All rights reserved.
Similar articles
- Is hormonal treatment still an option in acne today?Bettoli V, Zauli S, Virgili A.Bettoli V, et al.Br J Dermatol. 2015 Jul;172 Suppl 1:37-46. doi: 10.1111/bjd.13681.Br J Dermatol. 2015.PMID:25627824Review.
- Hormonal therapy for acne.George R, Clarke S, Thiboutot D.George R, et al.Semin Cutan Med Surg. 2008 Sep;27(3):188-96. doi: 10.1016/j.sder.2008.06.002.Semin Cutan Med Surg. 2008.PMID:18786497Review.
- Acne in the adult female patient: a practical approach.Kamangar F, Shinkai K.Kamangar F, et al.Int J Dermatol. 2012 Oct;51(10):1162-74. doi: 10.1111/j.1365-4632.2012.05519.x.Int J Dermatol. 2012.PMID:22994662Review.
- Practical approach to the hormonal treatment of acne.Poulin Y.Poulin Y.J Cutan Med Surg. 2004;8 Suppl 4:16-21. doi: 10.1007/s10227-004-0755-7.J Cutan Med Surg. 2004.PMID:15778820Review.
- Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy.Franks S, Layton A, Glasier A.Franks S, et al.Hum Reprod. 2008 Feb;23(2):231-2. doi: 10.1093/humrep/dem379. Epub 2007 Dec 14.Hum Reprod. 2008.PMID:18083746
Cited by
- Acne treatment: research progress and new perspectives.Li Y, Hu X, Dong G, Wang X, Liu T.Li Y, et al.Front Med (Lausanne). 2024 Jul 10;11:1425675. doi: 10.3389/fmed.2024.1425675. eCollection 2024.Front Med (Lausanne). 2024.PMID:39050538Free PMC article.Review.
- Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations.Dessinioti C, Katsambas A.Dessinioti C, et al.Yale J Biol Med. 2022 Dec 22;95(4):429-443. eCollection 2022 Dec.Yale J Biol Med. 2022.PMID:36568833Free PMC article.Review.
- Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience.Kim GK, Del Rosso JQ.Kim GK, et al.J Clin Aesthet Dermatol. 2012 Mar;5(3):37-50.J Clin Aesthet Dermatol. 2012.PMID:22468178Free PMC article.
- Modulating the Activity of Androgen Receptor for Treating Breast Cancer.You CP, Tsoi H, Man EPS, Leung MH, Khoo US.You CP, et al.Int J Mol Sci. 2022 Dec 5;23(23):15342. doi: 10.3390/ijms232315342.Int J Mol Sci. 2022.PMID:36499670Free PMC article.Review.
- Truncal Acne and Scarring: A Comprehensive Review of Current Medical and Cosmetic Approaches to Treatment and Patient Management.Daniele SG, Kim SR, Grada A, Moore AY, Suozzi KC, Bunick CG.Daniele SG, et al.Am J Clin Dermatol. 2023 Mar;24(2):199-223. doi: 10.1007/s40257-022-00746-4. Epub 2022 Dec 20.Am J Clin Dermatol. 2023.PMID:36539678Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical