Review
doi: 10.1042/BST0371334.The physiological properties and therapeutic potential of alpha5-GABAA receptors
Affiliations
- PMID:19909271
- DOI: 10.1042/BST0371334
Item in Clipboard
Review
The physiological properties and therapeutic potential of alpha5-GABAA receptors
Loren J Martin et al. Biochem Soc Trans.2009 Dec.
Display options
Format
Display options
Format
Abstract
The notion that drug treatments can improve memory performance has moved from the realm of science fiction to that of serious investigation. A popular working hypothesis is that cognition can be improved by altering the balance between excitatory and inhibitory neurotransmission. This review focuses on the unique physiological and pharmacological properties of GABA(A)Rs [GABA (gamma-aminobutyric acid) subtype A receptors] that contain the alpha(5) subunit (alpha(5)-GABA(A)R), as these receptors serve as candidate targets for memory-enhancing drugs.
Similar articles
- Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy.Ju YH, Guzzo A, Chiu MW, Taylor P, Moran MF, Gurd JW, MacDonald JF, Orser BA.Ju YH, et al.J Neurosci Res. 2009 Jun;87(8):1737-47. doi: 10.1002/jnr.21991.J Neurosci Res. 2009.PMID:19156871
- GABAA receptors: building the bridge between subunit mRNAs, their promoters, and cognate transcription factors.Steiger JL, Russek SJ.Steiger JL, et al.Pharmacol Ther. 2004 Mar;101(3):259-81. doi: 10.1016/j.pharmthera.2003.12.002.Pharmacol Ther. 2004.PMID:15031002Review.
- The complexity of the GABAA receptor shapes unique pharmacological profiles.D'Hulst C, Atack JR, Kooy RF.D'Hulst C, et al.Drug Discov Today. 2009 Sep;14(17-18):866-75. doi: 10.1016/j.drudis.2009.06.009. Epub 2009 Jul 2.Drug Discov Today. 2009.PMID:19576998Review.
- Role of GABAA receptors in cognition.Möhler H.Möhler H.Biochem Soc Trans. 2009 Dec;37(Pt 6):1328-33. doi: 10.1042/BST0371328.Biochem Soc Trans. 2009.PMID:19909270
- Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM.Chambers MS, et al.J Med Chem. 2003 May 22;46(11):2227-40. doi: 10.1021/jm020582q.J Med Chem. 2003.PMID:12747794
Cited by
- Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.Wu K, Han W, Tian Q, Li Y, Lu W.Wu K, et al.Cell Rep. 2021 Mar 23;34(12):108899. doi: 10.1016/j.celrep.2021.108899.Cell Rep. 2021.PMID:33761345Free PMC article.
- Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors.Jacob TC.Jacob TC.Front Mol Neurosci. 2019 Jul 24;12:179. doi: 10.3389/fnmol.2019.00179. eCollection 2019.Front Mol Neurosci. 2019.PMID:31396049Free PMC article.
- Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease.Brickley SG, Mody I.Brickley SG, et al.Neuron. 2012 Jan 12;73(1):23-34. doi: 10.1016/j.neuron.2011.12.012.Neuron. 2012.PMID:22243744Free PMC article.
- Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats.Zhao ZF, Du L, Gao T, Bao L, Luo Y, Yin YQ, Wang YA.Zhao ZF, et al.Neural Regen Res. 2019 Jun;14(6):1029-1036. doi: 10.4103/1673-5374.250621.Neural Regen Res. 2019.PMID:30762015Free PMC article.
- Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current.Jin Z, Jin Y, Kumar-Mendu S, Degerman E, Groop L, Birnir B.Jin Z, et al.PLoS One. 2011 Jan 14;6(1):e16188. doi: 10.1371/journal.pone.0016188.PLoS One. 2011.PMID:21264261Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources