Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

Wiley full text link Wiley Free PMC article
Full text links

Actions

Share

.2010 Apr 5;153B(3):775-85.
doi: 10.1002/ajmg.b.31046.

Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers

Affiliations

Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers

P E Adams et al. Am J Med Genet B Neuropsychiatr Genet..

Abstract

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder occurring in male and occasional female carriers of a premutation expansion (55-200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1). This study assessed the relationship between hippocampal volume and psychological symptoms in carriers, both with and without FXTAS, and controls. Volumetric MRI measures, clinical staging, cognitive testing, molecular analysis, and measures of psychological symptoms were performed for female premutation carriers both with FXTAS (n = 16, age: 57.50 + or - 12.46) and without FXTAS (n = 17, age: 44.94 + or - 11.23), in genetically normal female controls (n = 8, age: 50.63 + or - 11.43), male carriers with FXTAS (n = 34, age: 66.44 + or - 6.77) and without FXTAS (n = 21, age: 52.38 + or - 12.11), and genetically normal male controls (n = 30, age: 57.20 + or - 14.12). We examined the relationship between psychological symptom severity and hippocampal volume, as well as correlations with molecular data. We found a significant negative correlation between total hippocampal volume and anxiety in female carriers, with and without FXTAS. This finding was mainly driven by the significant negative correlation between right hippocampal volume and anxiety. Other anxiety-related subscales also correlated with the right hippocampus in females. In male carriers with and without FXTAS, only paranoid ideation negatively correlated with hippocampal volume. Female premutation carriers demonstrated a negative association between hippocampal volume and the severity of anxiety-related psychological symptoms. Though the presentation of FXTAS symptoms is less common in females, anxiety-related problems are common both prior to and after the onset of FXTAS, and may be related to hippocampal changes.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Comparison of anxiety score on SCL-90-R for males and females, with and without FXTAS, and controls. Closed diamonds indicate female data points, while open circles depict male data points.P-values are for comparisons of predicted means at the age of 60 (fitted ANCOVA model). We found female premutation carriers with FXTAS had significantly higher predicted scores at age 60 in the ANCOVA model as compared to female carriers without FXTAS (P=0.023), and controls (P=0.001*). In the same analysis, male premutation carriers with FXTAS also had higher levels of anxiety compared to male carriers without FXTAS (P=0.028) and controls (P=0.003*). *P-value retains significance following correction for multiple comparisons.
FIG. 2
FIG. 2
Comparison of anxiety score on the SCL-90-R with right hippocampal volume (normalized by TCV) in female premutation carriers (both with and without FXTAS). Closed triangles indicate female premutation carriers without FXTAS, whereas open circles represent female carriers with FXTAS. We found that anxiety score correlated significantly with the size of the right hippocampus (R=−0.634,P<0.001*). The same was true for several other subscales on the SCL-90-R. *P-value retains significance following correction for multiple comparisons.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adams JS, Adams PE, Nguyen D, Brunberg JA, Tassone F, Zhang W, Koldewyn K, Rivera SM, Grigsby J, Zhang L, et al. Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS) Neurology. 2007;69(9):851–859. - PubMed
    1. Allingham-Hawkins DJ, Babul-Hirji R, Chitayat D, Holden JJA, Yang KT, Lee C, Hudson R, Gorwill RH, Nolin SL, Glicksman A, et al. Fragile X premutation is a significant risk factor for premature ovarian failure: The international collaborative POF in fragile X study— Preliminary data. Am J Med Genet. 1999;83:322–325. - PMC - PubMed
    1. Arocena DG, Iwahashi CK, Won N, Beilina A, Ludwig AL, Tassone F, Schwartz PH, Hagerman PJ. Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. Hum Mol Genet. 2005;14(23):3661–3671. - PubMed
    1. Bacalman S, Farzin F, Bourgeois JA, Cogswell J, Goodlin-Jones BL, Gane LW, Grigsby J, Leehey MA, Tassone F, Hagerman RJ. Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: Newly described fronto-subcortical dementia. J Clin Psychiatry. 2006;67(1):87–94. - PubMed
    1. Bannerman DM, Grubb M, Deacon RM, Yee BK, Feldon J, Rawlins JN. Ventral hippocampal lesions affect anxiety but not spatial learning. Behav Brain Res. 2003;139(1–2):197–213. - PubMed

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full text links
Wiley full text link Wiley Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp