Epigenetics: definition, mechanisms and clinical perspective
- PMID:19711245
- PMCID: PMC2791696
- DOI: 10.1055/s-0029-1237423
Epigenetics: definition, mechanisms and clinical perspective
Abstract
A vast array of successive epigenetic modifications ensures the creation of a healthy individual. Crucial epigenetic reprogramming events occur during germ cell development and early embryogenesis in mammals. As highlighted by the large offspring syndrome with in vitro conceived ovine and bovine animals, any disturbance during germ cell development or early embryogenesis has the potential to alter epigenetic reprogramming. Therefore the complete array of human assisted reproductive technology (ART), starting from ovarian hormonal stimulation to embryo uterine transfer, could have a profound impact on the epigenetic state of human in vitro produced individuals. Although some investigators have suggested an increased incidence of epigenetic abnormalities in in vitro conceived children, other researchers have refuted these allegations. To date, multiple reasons can be hypothesized why irrefutable epigenetic alterations as a result of ART have not been demonstrated yet.
Thieme Medical Publishers.
References
- Waddington CH. The epigenotype. Endeavour. 1942;1:18–20.
- Waddington CH. Towards a Theoretical Biology. Edinburgh, Scotland: Edinburgh University Press; 1968. The Basic Ideas of Biology; pp. 1–32.
- Wu Ct, Morris JR. Genes, genetics, and epigenetics: a correspondence. Science. 2001;293(5532):1103–1105. - PubMed
- Daskalos A, Nikolaidis G, Xinarianos G, et al. Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int J Cancer. 2009;124(1):81–87. - PubMed
- Zaratiegui M, Irvine DV, Martienssen RA. Noncoding RNAs and gene silencing. Cell. 2007;128(4):763–776. - PubMed
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